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公开(公告)号：US20230116048A1
公开(公告)日：2023-04-13
申请号：US17989526
申请日：2022-11-17
IPC分类号： A61K31/713 , A61K9/00 , A61K9/08 , A61K9/19 , C07K16/28 , A61K47/69 , A61K47/26 , A61K47/50 , A61K31/15 , A61K31/74
摘要： The present invention relates to compositions comprising polyinosinic (poly(l)) and polycytidylic acid poly(C) molecules, or a salt and/or solvate thereof, comprising double-stranded polyribonucleotides formed by the respective single-stranded poly(l) and poly(C) molecules and methods of makig same. The present invention further relates to compositions wherein the disclosed respective poly(l) and poly(C) single-stranded molecules are annealed to thereby form double-stranded poly(l:C) molecules.
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公开(公告)号：US20210060054A1
公开(公告)日：2021-03-04
申请号：US17095059
申请日：2020-11-11
摘要： The present invention relates to compositions comprising particles, each of the respective particles comprising particles formed by polyribonucleotides and polymers. Specifically, the composition comprises a complex of at least one double-stranded polyribonucleotide, such as polyinosinic-polycytidylic acid [poly(I:C)], and at least one linear polyalkyleneimine. The particles are also characterized by their monomodal diameter distribution and z-average diameter within specific ranges. The present invention additionally relates to methods of manufacturing the compositions, and further to related pharmaceutical compositions useful for the treatment of any cell growth disorder characterized by an abnormal growth of human or animal cells.
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