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公开(公告)号：US20200316223A1
公开(公告)日：2020-10-08
申请号：US16824008
申请日：2020-03-19
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , Hillard Rubin
摘要： Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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公开(公告)号：US11951183B2
公开(公告)日：2024-04-09
申请号：US16824008
申请日：2020-03-19
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , Hillard Rubin
CPC分类号： A61K48/0066 , C12N15/86 , C12N2750/14143 , C12N2750/14152 , C12N2750/14171 , C12N2830/32
摘要： Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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3.发明申请公开(公告)号：US20210130794A1
公开(公告)日：2021-05-06
申请号：US17073862
申请日：2020-10-19
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , James Anthony McSwiggen , Jaime Michelle Prout , Danielle Lauren Sookiasian
IPC分类号： C12N7/00
摘要： Provided herein are adeno-associated virus (AAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cell. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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公开(公告)号：US20200289674A1
公开(公告)日：2020-09-17
申请号：US16798890
申请日：2020-02-24
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , Hillard Rubin
摘要： Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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5.发明申请公开(公告)号：US20190256867A1
公开(公告)日：2019-08-22
申请号：US16265684
申请日：2019-02-01
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , James Anthony McSwiggen , Jaime Michelle Prout , Danielle Lauren Sookiasian
IPC分类号： C12N15/90 , A61K35/761 , C12N7/00
摘要： Provided herein are adeno-associated virus (AAV) compositions that can restore phenylalanine hydroxylase (PAH) gene function in cell. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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公开(公告)号：US12064486B2
公开(公告)日：2024-08-20
申请号：US16798890
申请日：2020-02-24
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , Hillard Rubin
CPC分类号： A61K48/0066 , C12N15/86 , C12N2750/14143 , C12N2750/14152 , C12N2750/14171 , C12N2830/32
摘要： Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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公开(公告)号：US20190231901A1
公开(公告)日：2019-08-01
申请号：US16369879
申请日：2019-03-29
发明人： Albert Barnes Seymour , Seemin Seher Ahmed , Jason Boke Wright , Serena Nicole Dollive , Hillard Rubin
CPC分类号： A61K48/0066 , C12N15/86 , C12N2750/14143 , C12N2750/14152 , C12N2750/14171 , C12N2830/32
摘要： Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
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