公开(公告)号：US20240263180A1

公开(公告)日：2024-08-08

申请号：US18564938

申请日：2022-05-27

Applicant: HOWARD UNIVERSITY

Inventor： Qiyi TANG ,  Hua ZHU

IPC: C12N15/113 ,  A61P31/22

CPC classification number: C12N15/1131 ,  A61P31/22 ,  C12N2310/11 ,  C12N2320/33

Abstract: The present disclosure provides small complementary RNAs (scRNAs), compositions containing the same, and methods for using such small complementary RNAs as antivirals. The present disclosure provides, in more specific embodiments, scRNAs that are single-stranded and which are about 20-30 nucleotides (nt) long, and which are complementary to the intron of an essential viral gene, such as the major immediate early (MIE) gene of human cytomegalovirus (HCMV). Also provided herein are pharmaceutical compositions additionally containing a pharmaceutically acceptable carrier system, wherein the carrier system includes a cationic polymer which releases the scRNA in response to endosomal pH.