公开(公告)号：US20220323557A1

公开(公告)日：2022-10-13

申请号：US17634191

申请日：2020-08-07

Applicant: HUMANITAS MIRASOLE S.P.A. ,  HUMANITAS UNIVERSITY

Inventor： Marinos KALLIKOURDIS ,  Elisa MARTINI ,  Gianluigi CONDORELLI

IPC: A61K39/00 ,  C07K19/00 ,  A61K9/00 ,  A61P9/04 ,  A61P37/06 ,  C07K14/47 ,  C07K14/705 ,  C12N9/86 ,  G01N33/68

Abstract: The invention provides a new method for identifying peptide antigens relevant to a non-autoimmune disease involving T cell activation as well as novel peptides identified therefrom. The isolated peptides of the invention are useful in the diagnosis, prevention and/or treatment of a cardiovascular disease, more specifically heart failure (HF). The invention further provides a pharmaceutical composition comprising at least one isolated peptide of the invention and a pharmaceutically acceptable carrier, vehicle, excipient and/or diluent. The pharmaceutical composition of the invention is suitable to be orally administered as a tolerizing vaccine.

公开(公告)号：US20190079103A1

公开(公告)日：2019-03-14

申请号：US15773615

申请日：2016-11-07

Applicant: HUMANITAS MIRASOLE S.P.A.

Inventor： Gianluigi CONDORELLI ,  Achille ANSELMO ,  Chiara VIVIANI ANSELMI ,  Laura PAPA

IPC: G01N33/68 ,  G01N33/543

Abstract: The present invention refers to a method for characterizing and/or measuring and/or sorting the amount of cardiac-derived microvesicles, having the step of detecting CD172a marker on the microvesicles, in an isolated biological sample obtained from the subject.