公开(公告)号：US10907210B2

公开(公告)日：2021-02-02

申请号：US15104129

申请日：2014-12-16

Applicant: HUMANITAS MIRASOLE S.P.A.

Inventor： Luigi Laghi ,  Giuseppe Celesti

IPC: C12Q1/6886

Abstract: The present invention concerns a method for determining if a subject is affected by a colorectal or pancreatic cancer or for determining the stage and/or the progression of a colorectal cancer. By measuring the presence of a panel of m RNAs encoding for transcription factors/genes involved in epithelial to mesenchymal transition in a blood sample, wherein different mRNA levels of a set of genes comprising TWIST1, SLUG, ZEB2, ZEB1 and CDH1, are indicative of colorectal cancer or pancreatic cancer diagnosis, and/or of colorectal cancer stage at diagnosis, and/or of CRC metastatic progression after surgery. The invention concerns also the use of kits to work the method.