公开(公告)号：US09334502B2

公开(公告)日：2016-05-10

申请号：US14367926

申请日：2012-01-18

申请人： Haixiong Han ,  Xiangying Zhu ,  Qin Sun ,  Xuefeng Gu ,  Shenghua Xie ,  Yang Li ,  Yangsheng Jin ,  Honghua Qu ,  Yueqiong Cao

发明人： Haixiong Han ,  Xiangying Zhu ,  Qin Sun ,  Xuefeng Gu ,  Shenghua Xie ,  Yang Li ,  Yangsheng Jin ,  Honghua Qu ,  Yueqiong Cao

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2799/027 ,  C12Y207/11

摘要： The present invention discloses the use of a human NLK gene and associated drugs thereof. The present invention discloses the use of the NLK gene for tumor treatment, tumor diagnosis and drug preparation. The present invention further constructs an isolated molecule that attenuates expression of the NLK gene of tumor cells, cells comprising the isolated molecule and a NLK interference lentivirus, and discloses the use thereof as well. The isolated molecule or the NLK interference lentivirus that attenuates expression of the NLK gene provided in the present invention can specifically attenuate expression of the human NLK gene, especially the lentivirus, can effectively infect target cells, efficiently inhibit the expression of the NLK gene in target cells, and inhibit the growth of tumor cells, thus has great significance in tumor treatment.

摘要翻译： 本发明公开了人NLK基因及其相关药物的用途。 本发明公开了NLK基因用于肿瘤治疗，肿瘤诊断和药物制备的应用。 本发明还构建了分解的肿瘤细胞的NLK基因的表达，包含分离的分子的细胞和NLK干扰慢病毒的分离的分子，并且还公开了其使用。 本发明提供的NLK基因表达的分离分子或NLK干扰慢病毒可以特异性地减弱人NLK基因，特别是慢病毒的表达，能够有效地感染靶细胞，有效地抑制靶基因中NLK基因的表达 细胞，抑制肿瘤细胞的生长，对肿瘤治疗具有重要意义。

公开(公告)号：US20150005370A1

公开(公告)日：2015-01-01

申请号：US14367926

申请日：2012-01-18

申请人： Haixiong Han ,  Xiangying Zhu ,  Qin Sun ,  Xuefeng Gu ,  Shenghua Xie ,  Yang Li ,  Yangsheng Jin ,  Honghua Qu ,  Yueqiong Cao

发明人： Haixiong Han ,  Xiangying Zhu ,  Qin Sun ,  Xuefeng Gu ,  Shenghua Xie ,  Yang Li ,  Yangsheng Jin ,  Honghua Qu ,  Yueqiong Cao

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2799/027 ,  C12Y207/11

摘要： The present invention discloses the use of a human NLK gene and associated drugs thereof. The present invention discloses the use of the NLK gene for tumor treatment, tumor diagnosis and drug preparation. The present invention further constructs an isolated molecule that attenuates expression of the NLK gene of tumor cells, cells comprising the isolated molecule and a NLK interference lentivirus, and discloses the use thereof as well. The isolated molecule or the NLK interference lentivirus that attenuates expression of the NLK gene provided in the present invention can specifically attenuate expression of the human NLK gene, especially the lentivirus, can effectively infect target cells, efficiently inhibit the expression of the NLK gene in target cells, and inhibit the growth of tumor cells, thus has great significance in tumor treatment.

摘要翻译： 本发明公开了人NLK基因及其相关药物的用途。 本发明公开了NLK基因用于肿瘤治疗，肿瘤诊断和药物制备的应用。 本发明还构建了分解的肿瘤细胞的NLK基因的表达，包含分离的分子的细胞和NLK干扰慢病毒的分离的分子，并且还公开了其使用。 本发明提供的NLK基因表达的分离分子或NLK干扰慢病毒可以特异性地减弱人NLK基因，特别是慢病毒的表达，能够有效地感染靶细胞，有效地抑制靶基因中NLK基因的表达 细胞，抑制肿瘤细胞的生长，对肿瘤治疗具有重要意义。

公开(公告)号：US09434949B2

公开(公告)日：2016-09-06

申请号：US14239120

申请日：2011-08-16

申请人： Yueqiong Cao ,  Dalong Lv ,  Xiangying Zhu ,  Haixiong Han ,  Honghua Qu ,  Yangsheng Jin

发明人： Yueqiong Cao ,  Dalong Lv ,  Xiangying Zhu ,  Haixiong Han ,  Honghua Qu ,  Yangsheng Jin

IPC分类号： A61K48/00 ,  C12N15/113 ,  A61K45/06 ,  A61K31/7105 ,  A61K31/713

CPC分类号： C12N15/1135 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/113 ,  C12N2310/14 ,  C12N2740/15043 ,  A61K2300/00

摘要： The present invention discloses uses of the human ZFX gene and drugs associated therewith. Also disclosed are uses of the human ZFX gene in tumor treatment, tumor diagnosis, and drug preparation. Further disclosed are small interfering RNA (siRNA), and nucleic acid and lentivirus encoding the siRNA to the human ZFX gene and uses thereof. The siRNA and nucleic acid and lentivirus encoding the siRNA provided by the present invention can specifically inhibit the expression of human ZFX gene. Lentiviruses in particular can efficiently infect target cells, inhibit ZFX expression in target cells, and inhibit the growth of tumor cells, thus promote tumor apoptosis and have great significance in tumor treatment.

摘要翻译： 本发明公开了人ZFX基因及其相关药物的用途。 还公开了人ZFX基因在肿瘤治疗，肿瘤诊断和药物制备中的用途。 进一步公开的是小干扰RNA（siRNA）和编码人ZFX基因的siRNA的核酸和慢病毒及其用途。 编码本发明提供的siRNA的siRNA和核酸和慢病毒可以特异性抑制人ZFX基因的表达。 特异性病毒可以有效地感染靶细胞，抑制靶细胞中的ZFX表达，抑制肿瘤细胞的生长，从而促进肿瘤细胞凋亡，对肿瘤治疗具有重要意义。

公开(公告)号：US20140275219A1

公开(公告)日：2014-09-18

申请号：US14239120

申请日：2011-08-16

申请人： Yueqiong Cao ,  Dalong Lv ,  Xiangying Zhu ,  Haixiong Han ,  Honghua Qu ,  Yangsheng Jin

发明人： Yueqiong Cao ,  Dalong Lv ,  Xiangying Zhu ,  Haixiong Han ,  Honghua Qu ,  Yangsheng Jin

IPC分类号： C12N15/113

CPC分类号： C12N15/1135 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/113 ,  C12N2310/14 ,  C12N2740/15043 ,  A61K2300/00

摘要： The present invention discloses uses of the human ZFX gene and drugs associated therewith. Also disclosed are uses of the human ZFX gene in tumor treatment, tumor diagnosis, and drug preparation. Further disclosed are small interfering RNA (siRNA), and nucleic acid and lentivirus encoding the siRNA to the human ZFX gene and uses thereof. The siRNA and nucleic acid and lentivirus encoding the siRNA provided by the present invention can specifically inhibit the expression of human ZFX gene. Lentiviruses in particular can efficiently infect target cells, inhibit ZFX expression in target cells, and inhibit the growth of tumor cells, thus promote tumor apoptosis and have great significance in tumor treatment.

摘要翻译： 本发明公开了人ZFX基因及其相关药物的用途。 还公开了人ZFX基因在肿瘤治疗，肿瘤诊断和药物制备中的用途。 进一步公开的是小干扰RNA（siRNA）和编码人ZFX基因的siRNA的核酸和慢病毒及其用途。 编码本发明提供的siRNA的siRNA和核酸和慢病毒可以特异性抑制人ZFX基因的表达。 特异性病毒可以有效地感染靶细胞，抑制靶细胞中的ZFX表达，抑制肿瘤细胞的生长，从而促进肿瘤细胞凋亡，对肿瘤治疗具有重要意义。