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公开(公告)号：US07906657B2
公开(公告)日：2011-03-15
申请号：US12301067
申请日：2007-04-20
IPC分类号： C07D261/06 , C07D231/12 , C07D401/10 , C07D403/10 , A61K31/501 , A61K31/497 , A61K31/454 , A61K31/4427 , A61K31/415
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节 和/或调节HSP90起作用。
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公开(公告)号：US20100160352A1
公开(公告)日：2010-06-24
申请号：US12063384
申请日：2006-07-20
IPC分类号： A61K31/52 , C07D473/34 , A61P25/28
CPC分类号： C07D473/34
摘要： Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型腺嘌呤衍生物，其中R 1，R 2，R 3，X和Y具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。
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3.发明申请2-Amino-4-Phenylquinazoline Derivatives and the Use Thereof as Hsp90 Modulators 失效2-氨基-4-苯基喹唑啉衍生物及其用途作为Hsp90调节剂公开(公告)号：US20080214586A1
公开(公告)日：2008-09-04
申请号：US11914604
申请日：2006-04-24
IPC分类号： A61K31/517 , C07D239/84 , A61P1/00 , A61P3/00 , A61P25/00 , A61P29/00 , A61P35/04
CPC分类号： C07D401/12 , C07D239/84 , C07D403/12
摘要： Novel phenylquinazoline derivatives of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 新的式（I）的苯基喹唑啉衍生物，其中R 1，R 2，R 3，R 4， >和R 5具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗HSP90的抑制，调节和/或调节的疾病的药物 一名角色。
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公开(公告)号：US08119795B2
公开(公告)日：2012-02-21
申请号：US12301140
申请日：2007-04-20
IPC分类号： A61K31/4196 , C07D503/12 , C07D249/12 , C07D401/12
CPC分类号： C07D249/08 , C07D401/12 , C07D403/12
摘要： Novel triazole derivatives of the formula (I) in which R1-R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型三唑衍生物，其中R 1 -R 6和Y具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和/ 或调制HSP90起作用。
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公开(公告)号：US07977343B2
公开(公告)日：2011-07-12
申请号：US12063384
申请日：2006-07-20
IPC分类号： A61K31/535
CPC分类号： C07D473/34
摘要： Novel adenine derivatives of the formula (I), in which R1, R2, R3, X and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型腺嘌呤衍生物，其中R 1，R 2，R 3，X和Y具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。
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6.发明授权2-amino-4-phenylquinazoline derivatives and the use thereof as HSP90 modulators 失效2-氨基-4-苯基喹唑啉衍生物及其作为HSP90调节剂的用途公开(公告)号：US07947696B2
公开(公告)日：2011-05-24
申请号：US11914604
申请日：2006-04-24
IPC分类号： A61K31/517
CPC分类号： C07D401/12 , C07D239/84 , C07D403/12
摘要： Novel phenylquinazoline derivatives of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的苯基喹唑啉衍生物，其中R 1，R 2，R 3，R 4和R 5具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗疾病的药物 HSP90的抑制，调节和/或调节起着重要的作用。
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公开(公告)号：US20110028485A1
公开(公告)日：2011-02-03
申请号：US12883428
申请日：2010-09-16
IPC分类号： A61K31/415 , C07D231/12 , C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/496 , A61K31/4439 , A61K31/422 , A61K31/501 , A61K31/497 , A61P35/00 , A61P35/04 , A61P37/00 , A61P31/00 , A61P9/10 , A61P31/12 , A61P3/10 , A61P11/06 , A61P17/06 , A61P25/00 , A61P1/00
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节 和/或调节HSP90起作用。
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公开(公告)号：US20090325974A1
公开(公告)日：2009-12-31
申请号：US12301067
申请日：2007-04-20
IPC分类号： A61K31/501 , C07D231/12 , A61K31/415 , A61K31/496 , C07D403/12 , A61P35/00
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗其抑制，调节 和/或调节HSP90起作用。
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公开(公告)号：US08722903B2
公开(公告)日：2014-05-13
申请号：US12307030
申请日：2007-06-18
IPC分类号： C07D231/56 , A61K31/44
CPC分类号： C07D403/12 , C07D231/56 , C07D405/12
摘要： Novel indazole derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim (1), are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型吲唑衍生物，其中R1-R3具有权利要求（1）所示的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和 /或HSP90调节起作用。
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公开(公告)号：US20100022540A1
公开(公告)日：2010-01-28
申请号：US12301140
申请日：2007-04-20
IPC分类号： A61K31/4196 , C07D503/12 , C07D249/12 , C07D401/12 , C07D413/12 , C07D403/12 , A61K31/496 , A61K31/4439 , A61K31/5377 , A61P35/00 , A61P29/00 , A61P31/12 , A61P25/00
CPC分类号： C07D249/08 , C07D401/12 , C07D403/12
摘要： Novel triazole derivatives of the formula (I) in which R1—R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型三唑衍生物，其中R 1 -R 6和Y具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和/ 或调制HSP90起作用。
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