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1.发明授权
公开(公告)号：US5817697A
公开(公告)日：1998-10-06
申请号：US700402
申请日：1997-07-01
申请人： Hans-Michael Wolff , Dietrich Schacht , Martin Feelisch , Bruce Ramsay , John Francis Martin , Christoph Christopher Lees , Adam Julian De Belder
发明人： Hans-Michael Wolff , Dietrich Schacht , Martin Feelisch , Bruce Ramsay , John Francis Martin , Christoph Christopher Lees , Adam Julian De Belder
CPC分类号： A61K9/7053 , A61K31/21 , A61K9/7061 , A61K9/7076 , A61K9/7092
摘要： The pharmaceutical use of nitroglycerin, which is also designated as glycerol trinitrate or, chemically, as 1,2,3-propanetriol trinitrate, in a transdermal application form prevents undesired labour in pregnant mammals. The pharmaceutical use prevents premature labour.
摘要翻译： PCT No.PCT / EP95 / 00654 Sec。 371日期1997年7月1日 102（e）日期1997年7月1日PCT提交1995年2月22日PCT公布。 公开号WO95 / 22964 日期1995年8月31日硝酸甘油的药物用途也被称为甘油三硝酸酯，或者以化学方式称为三硝酸二丙三醇，以透皮施用形式防止怀孕哺乳动物的不期望的劳动。 药物用途可以防止过早劳动。
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2.发明授权Active ingredient patch for low-melting and/or volatile active ingredients 失效用于低熔点和/或挥发性活性成分的活性成分贴剂
公开(公告)号：US5603948A
公开(公告)日：1997-02-18
申请号：US483312
申请日：1995-06-07
CPC分类号： A61K9/7053 , A61K9/7076 , A61L15/58
摘要： A method of preparing a patch for the controlled release of readily available volatile active substances to the skin is disclosed. The patch comprises a back layer, and, bonded to the back layer, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive film. The pressure-sensitive fusion adhesive contains a triple-block copolymer of polystyrene block copoly(ethylene/butylene) block polystyrene at a concentration of 10 to 80% by wt., and an active substance at a concentration of 2.5 to 25% by weight, which is a readily volatile liquid at the temperature at which the adhesive bonds.
摘要翻译： 公开了一种制备用于将容易获得的挥发性活性物质控制释放到皮肤上的贴剂的方法。 贴片包括背层，并且与背层结合由压敏熔融粘合剂组成的水不溶性粘合剂膜，以及覆盖粘合剂膜的可拆卸膜。 压敏熔融粘合剂含有浓度为10〜80重量％的聚苯乙烯嵌段共聚（乙烯/丁烯）嵌段聚苯乙烯和浓度为2.5〜25重量％的活性物质的三嵌段共聚物， 其在粘合剂粘合的温度下是易挥发的液体。
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公开(公告)号：US20050079206A1
公开(公告)日：2005-04-14
申请号：US10623864
申请日：2003-07-22
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7076 , A61K31/38
摘要： An improved Transdermal Delivery System (TDS) comprising a backing layer inert to the components of the matrix, a self-adhesive matrix containing rotigotine and a protective foil or sheet to be removed prior to use, characterized in that the self-adhesive matrix consists of a solid or semi-solid semi-permeable polymer (1) wherein rotigotine in its free base form has been incorporated, (2) which is saturated with rotigotine and contains said rotigotine as a multitude of microreservoirs within the matrix, (3) which is highly permeable for the free base of rotigotine, (4) which is impermeable for the protonated form of rotigotine, (5) wherein the maximum diameter of the microreservoirs is less than the thickness of the matrix. is provided. Said TDS provides for enhanced flux of rotigotine across the TDS/skin interface.
摘要翻译： 一种改进的透皮递送系统（TDS），其包括对基质的组分是惰性的背衬层，含有罗替戈汀的自粘性基质和在使用前被去除的保护性箔或片，其特征在于，所述自粘性基质由 已经掺入其游离碱形式的罗替戈汀的固体或半固体半透性聚合物（1），（2）其被罗替戈汀饱和并且含有所述罗替戈汀作为基质内的多个微储层，（3） 高度可渗透的罗替戈汀的游离碱，（4）其对于质子化形式的罗替戈汀是不可渗透的，（5）其中微储层的最大直径小于基质的厚度。 被提供。 所述TDS提供通过TDS /皮肤界面的增强的罗替戈汀的通量。
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4.发明授权Active ingredient patch for low-melting and/or volatile active ingredients 失效用于低熔点和/或挥发性活性成分的活性成分贴剂
公开(公告)号：US5527536A
公开(公告)日：1996-06-18
申请号：US367262
申请日：1995-02-27
CPC分类号： A61K9/7053 , A61K9/7076 , A61L15/58
摘要： The invention concerns a patch for the controlled release of readily available volatile active substances to the skin, the patch comprising a back layer and, bonded to it, a water-insoluble adhesive film consisting of a pressure-sensitive fusion adhesive, plus a detachable film covering the adhesive film. The patch is characterized in that the pressure-sensitive fusion adhesive contains a triple-block copolymer of polystyrene block copoly(ethylene/butylene) block polystyrene (SEBS) at a concentration of 10 to 80% by wt., and an active substance which, at the temperature at which the adhesive bonds, is a readily volatile liquid, and which is present at a concentration of 2.5 to 25% by wt.
摘要翻译： PCT No.PCT / DE93 / 00638 Sec。 371日期：1995年2月27日 102（e）日期1995年2月27日PCT提交1993年7月17日PCT公布。 公开号WO94 / 02123 日期1994年2月3日。本发明涉及一种用于将容易获得的挥发性活性物质控制释放到皮肤上的贴剂，该贴剂包含背层并与其结合，由不溶于水的粘合剂组成的水不溶性粘合剂膜 熔融粘合剂，以及覆盖粘合剂膜的可拆卸膜。 该贴剂的特征在于，压敏熔融粘合剂含有浓度为10〜80重量％的聚苯乙烯嵌段共聚（乙烯/丁烯）嵌段聚苯乙烯（SEBS）的三嵌段共聚物和活性物质， 在粘合剂粘合的温度下，是易挥发的液体，其浓度为2.5至25重量％。
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5.发明申请Device for transdermal administration for the treatment of urinary tract disorders 审中-公开透皮给药装置用于治疗尿路疾病公开(公告)号：US20050226919A1
公开(公告)日：2005-10-13
申请号：US10497199
申请日：2002-09-12
IPC分类号： A61K9/70 , A61K31/403 , A61K31/405 , A61K31/4439
CPC分类号： A61K9/7061 , A61K31/403
摘要： This invention provides a device containing a compound of formula (I), wherein R represents a saturated or unsaturated C2-7 aliphatic acyl group optionally substituted by one or more halogen atoms, a hydroxy group, a C1-6 alkoxy group, a carboxyl group, a C2-7 alkoxycarbonyl group, a 5 to 7-membered cycloalkyl group, a phenyl or naphthyl group; a C2-6 hydroxyalkyl group; an aliphatic acyloxyalkyl group having a C2-7 acyl group and a C1-6 alkyl group; a C1-6 alkyl group substituted by a C1-6 alkoxy group, a carboxyl group, a C2-7 alkoxycarbonyl group, a C2-7 alkoxycarbonyl group substituted by a phenyl or naphthyl group, a carbamoyl group, a mono- or di-(C1-6 alkyl)-substituted carbamoyl group or a cyano group; a benzoyl or naphthoyl group optionally substituted by one or more halogen atoms; a furoyl group or a pyridylcarbonyl group; and R1 represents a C1-6 alkyl group optionally substituted by one or more halogen atoms, a phenyl or a naphthyl group; the carbon atom marked “*” represents a carbon atom in (R)-configuration, (S)-configuration or a mixture thereof. The TTS is efficient in the treatment of urinary tract disorders, such as benign prostatic hypertrophy.
摘要翻译： 本发明提供含有式（I）化合物的装置，其中R表示任选被一个或多个卤素原子取代的饱和或不饱和的C 2-7脂族酰基，羟基，C 羧基，C 2-7烷氧基羰基，5至7元环烷基，苯基或萘基; C 2-6羟基烷基; 具有C 2〜7酰基和C 1-6烷基的脂肪族酰氧基烷基; 被C 1-6烷氧基取代的C 1-6烷基，羧基，C 2-7烷氧基羰基， 被苯基或萘基取代的C 2〜2-7烷氧基羰基，氨基甲酰基，一或二 - （C 1-6烷基）取代的氨基甲酰基 或氰基; 任选被一个或多个卤素原子取代的苯甲酰基或萘甲酰基; 糠酰基或吡啶基羰基; R 1表示任选被一个或多个卤素原子，苯基或萘基取代的C 1-6烷基; 标有“*”的碳原子表示（R） - 构型，（S） - 构型或其混合物中的碳原子。 TTS有效治疗尿路疾病，如良性前列腺肥大。
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