公开(公告)号：US5308604A

公开(公告)日：1994-05-03

申请号：US859273

申请日：1992-03-26

申请人： Hansjorg Sinn ,  Hans-Hermann Schrenk ,  Wolfgang Maier-Borst ,  Eckhard Friedrich ,  Georgi Graschew ,  Dieter Worhle

发明人： Hansjorg Sinn ,  Hans-Hermann Schrenk ,  Wolfgang Maier-Borst ,  Eckhard Friedrich ,  Georgi Graschew ,  Dieter Worhle

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61K51/08 ,  A61K49/02 ,  A61K43/00

CPC分类号： A61K49/0002 ,  A61K47/48338 ,  A61K47/48715 ,  A61K51/0491 ,  A61K51/08 ,  A61K51/081 ,  A61K51/088 ,  A61K2123/00

摘要： The invention relates to conjugates composed ofa) at least one polyalcohol or a derivatized polyalcohol,b) at least one active agent,c) at least one linker andd) a protein,wherein the polyalcohol(s) or the derivatized polyalcohol(s) are polyalcohols or derivatized polyalcohols which are not recognized by the defense system of an organism as exogenous, and the protein is a protein which can be taken up by the tumor specifically or non-specifically, and is not recognized by the defense system of an organism as exogenous. These conjugates are suitable for, on the one hand, making possible a very sensitive method in nuclear medicine for the diagnosis of tumors and, on the other hand, for example also offering new methods for diagnosing tumors in X-ray diagnosis, computerized tomography, nuclear spin tomography, electron spin resonance spectroscopy or electron microscopy.

摘要翻译： 本发明涉及由a）至少一种多元醇或衍生化多元醇组成的缀合物，b）至少一种活性剂，c）至少一种连接体和d）蛋白质，其中所述多元醇或衍生化多元醇 ）是不被生物体的防御系统识别为外源的多元醇或衍生化多元醇，并且该蛋白质是可被肿瘤特异性或非特异性摄取的蛋白质，并且不被抗体系统识别 有机体为外源性。 这些缀合物一方面适合用于核医学中用于诊断肿瘤的非常敏感的方法，另一方面，例如还提供用于诊断X线诊断，计算机断层扫描， 核自旋断层扫描，电子自旋共振光谱或电子显微镜。