公开(公告)号：US20140249194A1

公开(公告)日：2014-09-04

申请号：US14264574

申请日：2014-04-29

申请人： Hanumant Bapurao BORATE ,  SANGESHWER PRABHAKAR SAWARGAVE ,  SUBHASH PRATAPRAO CHAVAN ,  MOHAN ANAND CHANDAVARKAR ,  RAMAKRISHNAN RAMACAHNDRAN IYER ,  AMIT CHANDRAKANT TAWTE ,  DEEPALI DAMODAR RAO

发明人： Hanumant Bapurao BORATE ,  SANGESHWER PRABHAKAR SAWARGAVE ,  SUBHASH PRATAPRAO CHAVAN ,  MOHAN ANAND CHANDAVARKAR ,  RAMAKRISHNAN RAMACAHNDRAN IYER ,  AMIT CHANDRAKANT TAWTE ,  DEEPALI DAMODAR RAO

IPC分类号： C07D409/12

CPC分类号： C07D409/12 ,  C07B2200/07

摘要： The invention discloses optically active compounds of Formula (1a) or Formula (1b), wherein R1 and R2 are independently selected from the group consisting of hydrogen and a halogen selected from the group consisting of fluorine, chlorine, bromine, and iodine; and wherein (a) R3 and R4 are independently selected from the group consisting of hydrogen and an alkyl group having a linear or branched chain having 1 to 20 carbon atoms, or (b) R3 and R4 together form a cycloalkyl ring having 3 to 10 carbon atoms fused to the thiophene ring; and wherein R5 is CN or COOR′, where R′ is methyl or ethyl. The compounds of Formula (1a) or Formula (1b) may be used in pharmaceutical compositions for treating fungal infections.

摘要翻译： 本发明公开了式（1a）或式（1b）的光学活性化合物，其中R 1和R 2独立地选自氢和选自氟，氯，溴和碘的卤素; 并且其中（a）R 3和R 4独立地选自氢和具有1至20个碳原子的直链或支链的烷基，或（b）R 3和R 4一起形成具有3至10个 与噻吩环稠合的碳原子; 并且其中R 5是CN或COOR'，其中R'是甲基或乙基。 式（1a）或式（1b）的化合物可用于治疗真菌感染的药物组合物中。