公开(公告)号：US20090029978A1

公开(公告)日：2009-01-29

申请号：US12178920

申请日：2008-07-24

申请人： Harold Francis HODSON ,  Christopher Robert DUNK ,  Richard Michael John PALMER ,  Dale Robert MITCHELL ,  Veronique BIRAULT ,  Russell George HUNT

发明人： Harold Francis HODSON ,  Christopher Robert DUNK ,  Richard Michael John PALMER ,  Dale Robert MITCHELL ,  Veronique BIRAULT ,  Russell George HUNT

IPC分类号： A61K31/5365 ,  C07D498/04 ,  A61P3/04 ,  A61P3/10 ,  C12N9/99

CPC分类号： C07D498/04 ,  C07D498/14

摘要： The use of a compound comprising formula (I), or a salt, ester, amide or prodrug thereof in the treatment of obesity and related disorders. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I): A is an optionally substituted thienyl moiety, Y is O, S, or NR2, R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups and R2 is hydrogen or a group as defined for R1.

摘要翻译： 包含式（I）化合物或其盐，酯，酰胺或前药的化合物在治疗肥胖症和相关病症中的用途。 本发明还涉及式（I）中的新化合物，其制备方法和含有它们的药物组合物。 在式（I）中：A是任选取代的噻吩基部分，Y是O，S或NR 2，R 1是支链或非支链烷基（任选被一个或多个氧原子中断），烯基，炔基，环烷基，环烯基，芳基 ，芳基烷基，还原芳基烷基，芳基烯基，杂芳基，杂芳基烷基，杂芳基烯基，还原芳基，还原杂芳基，还原的杂芳基烷基或任何前述基团的取代的衍生物，并且R 2是氢或如R1所定义的基团。