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公开(公告)号：USD399814S
公开(公告)日：1998-10-20
申请号：US69528
申请日：1997-04-24
Applicant: Andy Toro , Harry Howard
Designer： Andy Toro , Harry Howard
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公开(公告)号：US20060094719A1
公开(公告)日：2006-05-04
申请号：US11256339
申请日：2005-10-21
Applicant: Harry Howard , Mark Elliott
Inventor： Harry Howard , Mark Elliott
IPC: A61K31/5377 , A61K31/496 , A61K31/454 , C07D413/02 , C07D403/02 , C07D401/02
CPC classification number: C07D209/44 , C07D211/22 , C07D211/32 , C07D211/36 , C07D211/58 , C07D211/62 , C07D211/76 , C07D213/61 , C07D239/26 , C07D295/096 , C07D307/22 , C07D307/52 , C07D401/04
Abstract: This invention is directed to compounds of the formula I as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.
Abstract translation: 本发明涉及本文定义的式I化合物或其药学上可接受的盐; 含有式I化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用如上所述的式I化合物， 以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD），精神障碍，睡眠中的障碍或病症的方法 疾病，肥胖，头晕，癫痫，晕车，呼吸系统疾病，过敏，过敏引起的气道反应，过敏性鼻炎，鼻充血，过敏充血，充血，低血压，心血管疾病，胃肠道疾病，超低运动性和酸性 分泌胃肠道，该方法包括向需要这种治疗的哺乳动物施用化合物 我如上所述。
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公开(公告)号：US20050154135A1
公开(公告)日：2005-07-14
申请号：US10754045
申请日：2004-01-08
Applicant: Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John Wood , John Andries
Inventor： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John Wood , John Andries
CPC classification number: C08F8/50
Abstract: Toughened thermoplastic compositions comprising a thermoplastic polymer toughened by the inclusion of a thermoplastic elastomer derived from a particulate rubber dynamically vulcanized in the presence of a matrix polymer. The toughened thermoplastic composition exhibits properties including toughness, improved impact resistance, and improved hardness. The compositions are utilized wherever toughened, high performance polymers are desired. A method for forming the toughened polymer compositions is also described. Processing methods, such as rotational molding, utilizing the toughened polymer compositions are described.
Abstract translation: 增韧的热塑性组合物包含热塑性聚合物，所述热塑性聚合物通过包含衍生自在基体聚合物存在下动态硫化的颗粒状橡胶的热塑性弹性体而增韧。 增韧的热塑性组合物具有包括韧性，改进的耐冲击性和改善的硬度的性能。 组合物被用于任何增韧的地方，需要高性能聚合物。 还描述了形成增韧的聚合物组合物的方法。 描述了使用增韧的聚合物组合物的加工方法，例如旋转模塑。
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公开(公告)号：USD431521S
公开(公告)日：2000-10-03
申请号：US112292
申请日：1999-10-13
Applicant: Harry Howard , Tara Ann Howard
Designer： Harry Howard , Tara Ann Howard
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公开(公告)号：US07557162B2
公开(公告)日：2009-07-07
申请号：US10754045
申请日：2004-01-08
Applicant: Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
Inventor： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
CPC classification number: C08F8/50
Abstract: Toughened thermoplastic compositions comprising a thermoplastic polymer toughened by the inclusion of a thermoplastic elastomer derived from a particulate rubber dynamically vulcanized in the presence of a matrix polymer. The toughened thermoplastic composition exhibits properties including toughness, improved impact resistance, and improved hardness. The compositions are utilized wherever toughened, high performance polymers are desired. A method for forming the toughened polymer compositions is also described. Processing methods, such as rotational molding, utilizing the toughened polymer compositions are described.
Abstract translation: 增韧的热塑性组合物包含热塑性聚合物，所述热塑性聚合物通过包含衍生自在基体聚合物存在下动态硫化的颗粒状橡胶的热塑性弹性体而增韧。 增韧的热塑性组合物具有包括韧性，改进的耐冲击性和改善的硬度的性能。 组合物被用于任何增韧的地方，需要高性能聚合物。 还描述了形成增韧的聚合物组合物的方法。 描述了使用增韧的聚合物组合物的加工方法，例如旋转模塑。
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Patent Agency Ranking
公开(公告)号：US07041741B2
公开(公告)日：2006-05-09
申请号：US11030243
申请日：2005-01-06
Applicant: Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
Inventor： Raman Patel , Harry Howard , Marc Caruthers , Tonya McBride , John J. Wood, III , John C. Andries
CPC classification number: C08F8/50
Abstract: Toughened thermoplastic compositions comprising a thermoplastic polymer toughened by the inclusion of a thermoplastic elastomer derived from a particulate rubber dynamically vulcanized in the presence of a matrix polymer. The toughened thermoplastic composition exhibits properties including toughness, improved impact resistance, and improved hardness. The compositions are utilized wherever toughened, high performance polymers are desired. A method for forming the toughened polymer compositions is also described. Processing methods, such as rotational molding, utilizing the toughened polymer compositions are described.
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公开(公告)号：US20050282811A1
公开(公告)日：2005-12-22
申请号：US11152273
申请日：2005-06-14
Applicant: Harry Howard , Bishop Wlodecki
Inventor： Harry Howard , Bishop Wlodecki
IPC: A61K31/498 , C07D471/04 , C07D487/04
CPC classification number: C07D471/04
Abstract: This invention is directed to compounds of the formula I and II as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I or II, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I or II as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), psychotic disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy-induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro-intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I or II as described above.
Abstract translation: 本发明涉及如本文所定义的式I和II的化合物或其药学上可接受的盐; 含有式I或II化合物的药物组合物，治疗可通过拮抗组胺H3受体治疗的病症或病症的方法，所述方法包括向需要这种治疗的哺乳动物施用式I或II化合物 以及治疗选自抑郁症，情绪障碍，精神分裂症，焦虑症，阿尔茨海默氏病，注意力缺陷障碍（ADD），注意力缺陷多动障碍（ADHD） 过敏反应，过敏性鼻炎，鼻充血，过敏性充血，充血，低血压，心血管疾病，胃肠道疾病，过氧化物酶，过氧化物酶 胃肠道的运动不足和酸性分泌，所述方法包括向需要这种治疗的哺乳动物施用com 磅如式I或II所述。
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8.发明申请Combination of gamma-aminobutyric acid modulators and 5-HT1B receptor antagonists 审中-公开γ-氨基丁酸调节剂和5-HT1B受体拮抗剂的组合公开(公告)号：US20050182049A1
公开(公告)日：2005-08-18
申请号：US11046974
申请日：2005-01-31
Applicant: Harry Howard
Inventor： Harry Howard
IPC: A61K31/195 , A61K31/197 , A61K31/541 , A61K45/06
CPC classification number: A61K31/195 , A61K31/197 , A61K31/541 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to a pharmaceutical composition for treating a disorder or condition selected from the group consisting of hypertension, depression, generalized anxiety disorder, phobias, posttraumatic stress disorder, avoidant personality disorder, sexual dysfunction, eating disorders, obesity, chemical dependencies, cluster headache, migraine, pain, Alzheimer's disease, obsessive-compulsive disorder, panic disorder, memory disorders, Parkinson's diseases, endocrine disorders, cerebellar atazia, gastrointestinal tract disorders, negative symptoms of schizophrenia, premenstrual syndrome, Fibromyalgia Syndrome, stress incontinence, Tourette syndrome, trichotillomania, kleptomania, male impotence, cancer, chronic paroxysmal hemicrania and headache in a mammal, preferably a human, comprising (i) a γ-aminobutyric acid modulator or a pharmaceutically acceptable salt thereof, (ii) a 5-HT1B receptor antagonist or a pharmaceutically acceptable salt thereof, wherein the 5-HT1B receptor antagonist is selected from the group consisting of (A) a compound of the formula I as described in the specification and (B) a compound of the formula II as described in the specification, and optionally (iii) a pharmaceutically acceptable carrier.
Abstract translation: 本发明涉及一种用于治疗选自高血压，抑郁症，广泛性焦虑症，恐惧症，创伤后应激障碍，避孕人格障碍，性功能障碍，进食障碍，肥胖，化学依赖性，集群 头痛，偏头痛，疼痛，阿尔茨海默病，强迫症，惊恐障碍，记忆障碍，帕金森病，内分泌失调，小脑阿扎西亚，胃肠道疾病，精神分裂症阴性症状，经前综合征，纤维肌痛综合征，压力性尿失禁，图雷特综合征， 哺乳动物，优选人类的头痛，恐怖症，男性阳ence，癌症，慢性阵发性高血压和头痛，包括（i）γ-氨基丁酸调节剂或其药学上可接受的盐，（ii）5-HT 1B 受体拮抗剂或其药学上可接受的盐，其中 5-HT 1B 1受体拮抗剂选自（A）如说明书中所述的式I化合物和（B）如说明书中所述的式II化合物 ，和任选地（iii）药学上可接受的载体。
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公开(公告)号：USD584676S1
公开(公告)日：2009-01-13
申请号：US29287414
申请日：2007-08-03
Applicant: Harry Howard , David Wilcoxen
Designer： Harry Howard , David Wilcoxen
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公开(公告)号：US20080060569A1
公开(公告)日：2008-03-13
申请号：US11882628
申请日：2007-08-03
Applicant: Harry Howard , David Wilcoxen
Inventor： Harry Howard , David Wilcoxen
IPC: B63B35/71
Abstract: A pedal-powered kayak, the present invention offers a more rounded keel and stem which operates in the water leaving no or little wake in the front or the rear of the boat. Since little water passes into the boat there no rough ride. The hull further provides a pair of fullers integrally formed on hull and extending along each side of the hull from said keel to said stem to provide a greater wetting surface for the hull as kayak moves over a body of water. The hull also provides a pair of strakes for lifting the hull as the kayak increases speed over the water.
Abstract translation: 本发明提供了一种更加圆形的龙骨和杆，其在水中运行，在船的前部或后部没有留下或稍微的尾迹。 由于很少的水通过船没有粗暴的骑。 船体还提供了一对整体形成在船身上并且从船体的每侧延伸到所述杆身的一对充气器，以便随着皮艇在水体上移动而为船体提供更大的润湿表面。 船体还提供了一对用于提升船体的行李，因为皮划艇提高了水面的速度。
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