公开(公告)号：US20200309774A1

公开(公告)日：2020-10-01

申请号：US16312131

申请日：2017-06-20

Applicant: HealthTell Inc.

Inventor： Robert William GERWIEN ,  Theodore Michael TARASOW ,  Jonathan Scott MELNICK

IPC: G01N33/564 ,  G01N33/68

Abstract: Provided herein are methods, assays and devices for the differential diagnosis and detection of disease progression of autoimmune diseases. The methods, assays and devices provided herein produce and analyze binding patterns of peripheral-blood antibodies on mimetic peptide arrays that differentiate autoimmune diseases, and identify patients progressing to internal organ complications such as interstitial lung disease (ILD), and gastric antral vascular ectasia (GAVE), or renal involvement.

公开(公告)号：US20200209236A1

公开(公告)日：2020-07-02

申请号：US16348704

申请日：2017-11-10

Applicant: HealthTell Inc.

Inventor： Robert William GERWIEN ,  Theodore Michael TARASOW ,  Jonathan Scott MELNICK ,  Kathryn Frances SYKES ,  Michael William ROWE

IPC: G01N33/564

Abstract: The disclosed embodiments concern methods, devices, and systems for identifying candidate biomarkers useful for the diagnosis, prognosis, monitoring and screening and/or as targets for the treatment of diseases and conditions in subjects, in particular autoimmune and infectious diseases. The identification of candidate biomarkers is predicated on identifying discriminating peptides present on a peptide array, which can distinguish samples from different subjects having different health conditions by the binding patterns of antibodies present in the samples.

公开(公告)号：US20200064345A1

公开(公告)日：2020-02-27

申请号：US16488078

申请日：2018-02-22

Applicant: HealthTell Inc.

Inventor： Kathryn Frances SYKES ,  Robert William GERWIEN ,  Jonathan Scott MELNICK ,  Michael William ROWE ,  Theodore Michael TARASOW

IPC: G01N33/569 ,  C12Q1/70 ,  G01N33/576

Abstract: The disclosed embodiments concern non-invasive methods, and apparatus, and systems for identifying infections. The methods are predicated on identifying discriminating peptides present on a peptide array, which are differentially bound by the different mixtures of antibodies present in samples from subjects consequent to an infection relative to binding of mixtures of antibodies present in reference subjects.