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公开(公告)号：US20110015377A1
公开(公告)日：2011-01-20
申请号：US12812176
申请日：2009-01-09
申请人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , Sinkoo Yeo , Mahnhoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
发明人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , Sinkoo Yeo , Mahnhoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
IPC分类号： C07K1/36
摘要： The method of the present invention comprising successive column chromatography processes for the purification of an anthrax protective antigen can achieve an improved purity of the anthrax protective antigen product by effectively removing impurities (e.g., cellular residual proteins in the culture solution) without the loss of anthrax protective antigen. Therefore, the method of the present invention can be advantageously used for economically producing the anthrax protective antigen on a large scale.
摘要翻译： 包含用于纯化炭疽保护性抗原的连续柱层析方法的本发明的方法可以通过有效地除去杂质（例如培养液中的细胞残留蛋白质）而不损失炭疽来实现改善的炭疽保护性抗原产物的纯度 保护性抗原。 因此，本发明的方法可有利地用于大规模经济地生产炭疽保护抗原。
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公开(公告)号：US08519108B2
公开(公告)日：2013-08-27
申请号：US12812176
申请日：2009-01-09
申请人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , SinKoo Yeo , MahnHoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
发明人： Hee-Bok Oh , Bong-Su Kim , Gi-Eun Rhie , Jeong-Hoon Chun , Hun Kim , SinKoo Yeo , MahnHoon Park , Chong-Hwan Jonathan Chang , Mi Sun Ahn
IPC分类号： C07K14/32
摘要： The method of the present invention comprising successive column chromatography processes for the purification of an anthrax protective antigen can achieve an improved purity of the anthrax protective antigen product by effectively removing impurities (e.g., cellular residual proteins in the culture solution) without the loss of anthrax protective antigen. Therefore, the method of the present invention can be advantageously used for economically producing the anthrax protective antigen on a large scale.
摘要翻译： 包含用于纯化炭疽保护性抗原的连续柱层析方法的本发明的方法可以通过有效地除去杂质（例如培养液中的细胞残留蛋白质）而不损失炭疽来实现改善的炭疽保护性抗原产物的纯度 保护性抗原。 因此，本发明的方法可有利地用于大规模经济地生产炭疽保护抗原。
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