公开(公告)号：US4730068A

公开(公告)日：1988-03-08

申请号：US831913

申请日：1986-02-21

申请人： Helmut Schonenberger ,  Erwin von Angerer ,  Johann Karl ,  Margaretha Jennerwein ,  Jurgen Engel

发明人： Helmut Schonenberger ,  Erwin von Angerer ,  Johann Karl ,  Margaretha Jennerwein ,  Jurgen Engel

IPC分类号： A61K31/28 ,  A61P35/00 ,  C07C45/29 ,  C07C45/51 ,  C07C45/56 ,  C07C47/575 ,  C07F15/00

CPC分类号： C07F15/0093 ,  C07C45/298 ,  C07C45/515 ,  C07C45/562 ,  C07C47/575

摘要： There are disclosed antitumor active 1,2-diphenyl-ethylenediamine)-platinum(II)-complex of the general formula ##STR1## wherein R.sub.7 is hydrogen or C.sub.1 -C.sub.6 -alkyl and R.sub.2 is either (1) a halogen atom and the groups R.sub.1, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are the same or different and are hydrogen, halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydrogen C.sub.1 -C.sub.6 -alkoxy, a C.sub.2 -C.sub.6 -alkanoyloxy or a halo or C.sub.1 -C.sub.4 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group, or R.sub.2 is (2) a hydroxy group, a C.sub.1 -C.sub.6 -alkoxy group, a C.sub.2 -C.sub.6 -alkanoyloxy group in the 4-position or a halo or C.sub.1 -C.sub.4 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group and if R.sub.2 is (2) then the groups R.sub.1 and R.sub.3 which are the same or differnt are in the 2 and 6 positions of the phenyl group and are halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, a C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alklanoyloxy group or a halo or C.sub.1 -C.sub.5 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group, with the proviso that R.sub.1 can also be hydrogen and the groups R.sub.4, R.sub.5, and R.sub.6 are the same or different and are hydrogen, halogen, trihalomethyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, a C.sub.2 -C.sub.6 -alkanoyloxy group or a halo or C.sub.1 -C.sub.4 -alkanesulfonyloxy substituted C.sub.2 -C.sub.6 -alkanoyloxy group and X is the equivalent of a physiologically compatible anion and process of their production.

摘要翻译： 公开了具有通式“IMAGE”I的抗肿瘤活性的1,2-二苯基 - 乙二胺） - 铂（II） - 复合物，其中R 7是氢或C 1 -C 6 - 烷基，R 2是（1）卤素原子， 基团R 1，R 3，R 4，R 5和R 6相同或不同，为氢，卤素，三卤甲基，C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烷酰氧基或卤素或C 1 -C 4 - 烷磺酰氧基取代的C 2 -C 6 - 烷酰氧基，或R 2为（2）羟基，C 1 -C 6 - 烷氧基，C 4 -C 6 - 烷酰氧基或卤素或C 1 -C 4 - 烷磺酰氧取代 C 2 -C 6 - 烷酰氧基，如果R 2为（2），则相同或不同的基团R 1和R 3为苯基的2和6位，为卤素，三卤代甲基，C 1 -C 6烷基，羟基， C 1 -C 6 - 烷氧基，C 2 -C 6 - 烷酰氧基或卤素或C 1 -C 5 - 烷磺酰氧基取代的C 2 -C 6 - 烷酰氧基，条件是R 1也可以是氢，基团R 4，R 5和R 6是 相同或不同的 氢，卤素，三卤代甲基，C 1 -C 6 - 烷基，羟基，C 1 -C 6 - 烷氧基，C 2 -C 6 - 烷酰氧基或卤素或C 1 -C 4 - 烷磺酰氧基取代的C 2 -C 6 - 烷酰氧基，X等同于 生理上相容的阴离子及其生产方法。

公开(公告)号：US4598091A

公开(公告)日：1986-07-01

申请号：US580238

申请日：1984-02-15

申请人： Helmut Schonenberger ,  Beate Wappes ,  Margaretha Jennerwein ,  Erwin von Angerer ,  Jurgen Engel

发明人： Helmut Schonenberger ,  Beate Wappes ,  Margaretha Jennerwein ,  Erwin von Angerer ,  Jurgen Engel

IPC分类号： A61K31/28 ,  A61K31/555 ,  A61P35/00 ,  C07F15/00 ,  A01N55/02 ,  A61K31/32

CPC分类号： C07F15/0093

摘要： There are prepared antitumor active (1,2-diphenyl-ethylenediamine)-platinum (II) complex compounds of the formula ##STR1## where the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen, hydroxy groups, C.sub.1 -C.sub.6 -alkoxy groups, C.sub.2 -C.sub.6 -alkanoyloxy groups which optionally are substituted by halogen atoms or C.sub.1 -C.sub.4 -alkanesulfonyloxy groups or C.sub.3 -C.sub.6 -alkenoyloxy groups and at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is not hydrogen and X is the equivalent of a physiologically compatible or pharmaceutically acceptable anion.

摘要翻译： 制备式Ⅰ的抗肿瘤活性（1,2-二苯基 - 乙二胺） - 铂（II）配合物，其中基团R 1，R 2，R 3和R 4相同或不同，为氢，羟基， C 1 -C 6烷氧基，任选被卤素原子或C 1 -C 4烷基磺酰氧基或C 3 -C 6 - 烯酰氧基取代的C 2 -C 6 - 烷酰氧基，R 1，R 2，R 3和R 4中的至少一个不是氢， X相当于生理上相容或药学上可接受的阴离子。