公开(公告)号：US08258175B2

公开(公告)日：2012-09-04

申请号：US11574531

申请日：2005-08-26

申请人： Hendrika Maria Gerarda Willems ,  Per Kallblad ,  Ian Robert Hardcastle ,  Roger John Griffin ,  Bernard Thomas Golding ,  John Lunec ,  Martin E. M. Noble ,  David R. Newell ,  Alan H. Calvert

发明人： Hendrika Maria Gerarda Willems ,  Per Kallblad ,  Ian Robert Hardcastle ,  Roger John Griffin ,  Bernard Thomas Golding ,  John Lunec ,  Martin E. M. Noble ,  David R. Newell ,  Alan H. Calvert

IPC分类号： A61K31/4015 ,  C07D209/46

CPC分类号： C07D209/50 ,  C07D209/48 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12

摘要： A compound of formula or a prodrug and/or a pharmaceutically acceptable salt thereof, wherein X is O, N or S; R1 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; R2 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; R3 is hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; and R4-R7, is used to represent groups R4, R5, R6 and R7 which are H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, halo, CF3, NH2, NO2, COOH, C═O.

摘要翻译： 式或其前药和/或其药学上可接受的盐的化合物，其中X为O，N或S; 取代或未取代的烷基胺，烷氧基，取代或未取代的芳基或杂芳基，以及取代或未取代的芳烷基或杂芳烷基; R 1为氢，卤素，羟基， R2是氢，卤素，羟基，取代或未取代的烷基，取代或未取代的羟基烷基取代或未取代的烷基胺，烷氧基，取代或未取代的芳基或杂芳基，以及取代或未取代的芳烷基或杂烷基; 取代或未取代的烷基胺烷氧基，取代或未取代的芳基或杂芳基，以及取代或未取代的芳烷基或杂烷基; R 3为氢，卤素，羟基， H，OH，烷基，烷氧基，烷基胺，羟基烷基，卤素，CF 3，NH 2，NO 2，COOH，C = O的基团R 4，R 5，R 6和R 7。