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公开(公告)号：US07989657B2
公开(公告)日：2011-08-02
申请号：US12477525
申请日：2009-06-03
申请人： Henrietta Dehmlow , Uwe Grether , Nicole A Kratochwil , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters
发明人： Henrietta Dehmlow , Uwe Grether , Nicole A Kratochwil , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters
IPC分类号： C07C235/00 , C07C229/56
CPC分类号： C07D215/26 , C07C235/56 , C07C255/54 , C07C317/22 , C07D213/643 , C07D213/65 , C07D249/08
摘要： The invention is concerned with novel anthranilic acid derivatives of formula (I) wherein R1 to R14, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型邻氨基苯甲酸衍生物，其中R 1至R 14，m和n如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。 这些化合物是HM74A激动剂，可用作药物。
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公开(公告)号：US07572801B2
公开(公告)日：2009-08-11
申请号：US11801863
申请日：2007-05-11
申请人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
发明人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
IPC分类号： A61K31/519 , C07D471/04 , A61P9/10 , A61P3/00 , A61P3/10
CPC分类号： C07D471/04
摘要： The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with improved properties compared to niacin and can be used for the treatment and/or prevention of diseases such as dyslipidemia, atherosclerosis, diabetes, metabolic syndrome, and other related diseases associated with HM74A.
摘要翻译： 本发明涉及式（I）的新颖的吡啶并嘧啶酮衍生物：其中R1至R8，X，Y，m和n如说明书和权利要求中所定义。 本发明的化合物是与烟酸相比具有改进性质的HM74A激动剂，可用于治疗和/或预防诸如血脂异常，动脉粥样硬化，糖尿病，代谢综合征和与HM74A相关的其它相关疾病的疾病。
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公开(公告)号：US20090247637A1
公开(公告)日：2009-10-01
申请号：US12477525
申请日：2009-06-03
申请人： Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters
发明人： Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters
IPC分类号： A61K31/196 , C07C229/66 , A61P9/00
CPC分类号： C07D215/26 , C07C235/56 , C07C255/54 , C07C317/22 , C07D213/643 , C07D213/65 , C07D249/08
摘要： The invention is concerned with novel anthranilic acid derivatives of formula (I) wherein R1 to R14, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型邻氨基苯甲酸衍生物，其中R 1至R 14，m和n如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。 这些化合物是HM74A激动剂，可用作药物。
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公开(公告)号：US20070275987A1
公开(公告)日：2007-11-29
申请号：US11801863
申请日：2007-05-11
申请人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
发明人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters , Fabienne Ricklin , Stephan Roever
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The invention is concerned with novel pyridopyrimidinone derivatives of formula (I): wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims. The compounds of the present invention are HM74A agonists with improved properties compared to niacin and can be used for the treatment and/or prevention of diseases such as dyslipidemia, atherosclerosis, diabetes, metabolic syndrome, and other related diseases associated with HM74A.
摘要翻译： 本发明涉及式（I）的新型吡啶并嘧啶酮衍生物：其中R 1至R 8，X，Y，m和n如说明书和 索赔。 本发明的化合物是与烟酸相比具有改进性质的HM74A激动剂，可用于治疗和/或预防诸如血脂异常，动脉粥样硬化，糖尿病，代谢综合征和与HM74A相关的其它相关疾病的疾病。
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公开(公告)号：US07928106B2
公开(公告)日：2011-04-19
申请号：US12049460
申请日：2008-03-17
申请人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos G. Panousis , Jens-Uwe Peters , Fabienne Ricklin
发明人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos G. Panousis , Jens-Uwe Peters , Fabienne Ricklin
IPC分类号： A61K31/50 , A61K31/501 , C07D487/00
CPC分类号： C07D487/04 , C07D475/02
摘要： The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, X1, X2, X3, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used in treating or preventing diseases which are modulated by HM74A agonists.
摘要翻译： 本发明涉及式（I）的新的氮杂 - 吡啶并嘧啶酮衍生物：其中R1，R2，R3，R4，R5，X1，X2，X3，Y，Z，m和n如说明书和权利要求书中所定义 ，以及其生理上可接受的盐和酯。 这些化合物是HM74A激动剂，可用于治疗或预防由HM74A激动剂调节的疾病。
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公开(公告)号：US20080234277A1
公开(公告)日：2008-09-25
申请号：US12049460
申请日：2008-03-17
申请人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos G. Panousis , Jens-Uwe Peters , Fabienne Ricklin
发明人： Aurelia Conte , Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Holger Kuehne , Robert Narquizian , Constantinos G. Panousis , Jens-Uwe Peters , Fabienne Ricklin
IPC分类号： A61K31/53 , C07D471/04 , C07D475/00 , A61K31/5025 , A61K31/519 , A61P9/10
CPC分类号： C07D487/04 , C07D475/02
摘要： The invention is concerned with novel aza-pyridopyrimidinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, X1, X2, X3, Y, Z, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used in treating or preventing diseases which are modulated by HM74A agonists.
摘要翻译： 本发明涉及式（I）的新型氮杂 - 吡啶并嘧啶酮衍生物：其中R 1，R 2，R 3，R SUP R 4，R 5，X 1，X 2，X 3，Y，Z ，m和n如在说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物是HM74A激动剂，可用于治疗或预防由HM74A激动剂调节的疾病。
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公开(公告)号：US20060281810A1
公开(公告)日：2006-12-14
申请号：US11451005
申请日：2006-06-12
申请人： Henrietta Dehmlow , Uwe Grether , Nicole Kratochwil , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters
发明人： Henrietta Dehmlow , Uwe Grether , Nicole Kratochwil , Robert Narquizian , Constantinos Panousis , Jens-Uwe Peters
IPC分类号： A61K31/277 , A61K31/195 , C07C255/60 , C07C237/02
CPC分类号： C07D215/26 , C07C235/56 , C07C255/54 , C07C317/22 , C07D213/643 , C07D213/65 , C07D249/08
摘要： The invention is concerned with novel anthranilic acid derivatives of formula (I) wherein R1 to R14 and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型邻氨基苯甲酸衍生物，其中R 1至R 14和n如说明书和权利要求书中所定义，以及 其生理上可接受的盐和酯。 这些化合物是HM74A激动剂，可用作药物。
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公开(公告)号：US20070072873A1
公开(公告)日：2007-03-29
申请号：US11524145
申请日：2006-09-20
申请人： Henrietta Dehmlow , Uwe Grether , Nicole Kratochwil , Robert Narquizian , Constantinos Panousis
发明人： Henrietta Dehmlow , Uwe Grether , Nicole Kratochwil , Robert Narquizian , Constantinos Panousis
IPC分类号： A61K31/513 , A61K31/497 , A61K31/4436 , A61K31/381 , C07D409/02
CPC分类号： C07D409/12 , C07D333/38
摘要： The invention is concerned with novel substituted thiophene derivatives of formula (I) wherein R1 to R8, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
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公开(公告)号：US07732452B2
公开(公告)日：2010-06-08
申请号：US11638220
申请日：2006-12-13
申请人： Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Robert Narquizian , Constantinos G. Panousis
发明人： Henrietta Dehmlow , Uwe Grether , Nicole A. Kratochwil , Robert Narquizian , Constantinos G. Panousis
IPC分类号： A61K31/497 , C07D409/02
CPC分类号： C07D409/12 , C07D333/38
摘要： The invention is concerned with novel substituted thiophene derivatives of formula (I) wherein R1 to R8, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型取代噻吩衍生物，其中R 1至R 8，X，m和n如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。 这些化合物是HM74A激动剂，可用作药物。
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公开(公告)号：US20070161650A1
公开(公告)日：2007-07-12
申请号：US11638220
申请日：2006-12-13
申请人： Henrietta Dehmlow , Uwe Grether , Nicole Kratochwil , Robert Narquizian , Constantinos Panousis
发明人： Henrietta Dehmlow , Uwe Grether , Nicole Kratochwil , Robert Narquizian , Constantinos Panousis
IPC分类号： A61K31/497 , A61K31/513 , A61K31/4436 , A61K31/381 , C07D409/02
CPC分类号： C07D409/12 , C07D333/38
摘要： The invention is concerned with novel substituted thiophene derivatives of formula (I) wherein R1 to R8, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新的取代噻吩衍生物，其中R 1至R 8，X，m和n如说明书和权利要求书中所定义 ，以及其生理上可接受的盐和酯。 这些化合物是HM74A激动剂，可用作药物。
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