公开(公告)号：US4022806A

公开(公告)日：1977-05-10

申请号：US643902

申请日：1975-12-23

申请人： Henry Francis Frost ,  Fritz Fabian ,  Christopher James Sharpe ,  William Arthur Jones

发明人： Henry Francis Frost ,  Fritz Fabian ,  Christopher James Sharpe ,  William Arthur Jones

IPC分类号： C07J9/00

CPC分类号： C07J9/005

摘要： A process for preparing a form of chenodeoxycholic acid having a melting point of ca. 166.degree. C from the amorphous form of the acid or from the form melting at ca. 120.degree. C. The amorphous or low melting forms of chenodeoxycholic acid, in a suspension in water, are seeded with preprepared crystalline acid of the high melting form and the acid product treated, in suspension, at a temperature of not greater than 85.degree. C to complete the conversion of the chenodeoxycholic acid to the high melting form. Crude chenodeoxycholic acid of the low melting form is purified by a process which involves forming a mixture of the crude acid, methanol, a base and a calcium or strontium salt, separating the precipitated crystalline calcium or strontium chenodeoxycholanate, dissolving the salt in a solution of acetic or propionic acid, diluting the solution with water to precipitate the free acid in purified form and recovering the purified acid.

摘要翻译： 一种制备具有约5％熔点的鹅脱氧胆酸形式的方法 166°C，由无定形形式的酸或熔点约为 120℃。在脱水的悬浮液中的鹅脱氧胆酸的无定形或低熔点形式用预制备的高熔点结晶酸和在不高于85℃的温度下悬浮处理的酸产物 以完成鹅脱氧胆酸转化为高熔点形式。 通过包括形成粗酸，甲醇，碱和钙或锶盐的混合物的方法纯化低熔点形式的粗脱氧胆酸，分离沉淀的结晶钙或hen脱氧胆酸锶，将盐溶解在 乙酸或丙酸，用水稀释溶液以沉淀出纯化形式的游离酸并回收纯化的酸。