公开(公告)号：US5166430A

公开(公告)日：1992-11-24

申请号：US585743

申请日：1990-09-20

申请人： Henry Szczepanski ,  Willy Meyer ,  Franz Weibel

发明人： Henry Szczepanski ,  Willy Meyer ,  Franz Weibel

IPC分类号： B01J23/40 ,  B01J23/755 ,  C07B61/00 ,  C07C319/14 ,  C07C319/18 ,  C07C323/67 ,  C07D521/00

CPC分类号： C07D521/00 ,  C07C323/67

摘要： A 2-(2-halogenoethylthio)-phenylsulfonamide of the formula I ##STR1## in which Z.sub.1 and Z.sub.2 independently of one another are hydrogen, fluorine or chlorine, is prepared by a process wherein:a) a 2-halogenophenylsulfonamide of the formula II ##STR2## in which X is fluorine, chlorine or bromine, is converted, in the presence of a base, together with a mercaptan of the formula IIIR-SH (III) in which R is C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkyl substituted by phenyl, into a 2-sulfenylphenylsulfonamide,b) this compound is oxidized to give the 2-sulfinylphenylsulfonamide,c) the resulting 2-sulfinylphenylsulfonamide is converted, in the presence of an acid, into the disulfide of the formula VI ##STR3## d) the disulfide of the formula VI is reduced to the 2-mercaptophenylsulfonamide,e) this compound is then converted, by means of a trialkylamine of the formula X(R.sub.1).sub.3 N (X) in which R.sub.1 is C.sub.1 -C.sub.4 alkyl, into the 2-mercaptophenylsulfonamide trialkylamine salt, andf) this compound is then reacted with a halogenofluoroethane of the formula IXY-CH.sub.2 CFZ.sub.1 Z.sub.2 (IX) in which Y is chlorine or bromine and Z.sub.1 and Z.sub.2 independently of one another are hydrogen, fluorine or chlorine.

摘要翻译： 其中Z 1和Z 2彼此独立地为氢，氟或氯的式I（I）的2-（2-卤代乙硫基） - 苯基磺酰胺是通过以下方法制备的，其中：a）将2-卤代苯基磺酰胺 其中X是氟，氯或溴的式II（II）在碱的存在下与式III的硫醇R-SH（III）一起转化，其中R是C 1 -C 6烷基 或被苯基取代的C1-C6烷基取代成2-亚磺酰基苯基磺酰胺，b）将该化合物氧化得到2-亚磺酰基苯基磺酰胺，c）将所得的2-亚磺酰基苯基磺酰胺在酸存在下转化成式 （VI）d）将式VI的二硫化物还原成2-巯基苯基磺酰胺，e）然后通过式X（R1）3N（X）的三烷基胺将该化合物转化为其中R1 是C 1 -C 4烷基，进入2-巯基苯基磺酰胺三烷基胺盐，f）然后使该化合物反应 其中Y为氯或溴，Z 1和Z 2彼此独立地为氢，氟或氯，式IXY-CH2CFZ1Z2（IX）的卤代氟代乙烷。