公开(公告)号：US20220098165A1

公开(公告)日：2022-03-31

申请号：US17426301

申请日：2020-01-28

申请人： Heptares Therapeutics Limited

发明人： Giles Albert Brown ,  Miles Stuart Congreve ,  John Andrew Christopher ,  Nigel Alan Swain ,  Sarah Joanne Bucknell ,  Anne Mary Stephenson ,  Benjamin Gerald Tehan ,  Geraint Jones ,  Mark Mills ,  Anil Patel ,  Andrew William Phillips

IPC分类号： C07D401/04 ,  C07D401/14

摘要： The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein V; W; X; Y; Z; R1; R2; R3; R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

公开(公告)号：US20210179578A1

公开(公告)日：2021-06-17

申请号：US16760807

申请日：2018-11-05

申请人： Heptares Therapeutics Limited

发明人： John Andrew Christopher ,  Sarah Joanne Bucknell ,  Miles Stuart Congreve ,  Benjamin Gerald Tehan ,  Rebecca Helen Nonoo ,  Giles Albert Brown ,  Nigel Alan Swain ,  Mark Mills

IPC分类号： C07D401/04 ,  C07D243/04

摘要： The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein X; Y; R1; R2; R3; R4; R5; R6; R7 and R8 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.