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1.发明申请Pharmaceutical preparation with retarding active ingredient release, method for its production and its use 有权具有延缓活性成分释放的药物制剂，其制备方法及其用途公开(公告)号：US20040052841A1
公开(公告)日：2004-03-18
申请号：US10600557
申请日：2003-06-20
IPC分类号： A61K038/14 , A61K031/739 , A61K031/704 , A61K031/545 , A61K009/22
CPC分类号： A61K9/0024 , A61K9/2009 , A61K9/204 , A61K38/14 , A61K45/06 , A61K2300/00
摘要： The invention describes pharmaceutical preparations with retarding active ingredient release, which consist of mixtures of powdery teicoplanin and at least one powdery, water soluble salt form of gentamicin, clindamycin, kanamycin, amikacin, tobramycin, vancomycin, moxifloxacin and ciprofloxacin and an inorganic and/or organic adjuvant. The pharmaceutical preparations are used as permanent or as temporary implants in the form of tablets, molded bodies, fibers and granules.
摘要翻译： 本发明描述了具有延迟活性成分释放的药物制剂，其由替考拉宁粉末与至少一种粉末状水溶性盐形式的庆大霉素，克林霉素，卡那霉素，阿米卡星，妥布霉素，万古霉素，莫西沙星和环丙沙星以及无机和/或 有机佐剂。 药物制剂用作片剂，成型体，纤维和颗粒形式的永久或临时植入物。
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2.发明申请Antibiotic coating for porous bodies and method for its production as well as its use 有权多孔体的抗生素涂层及其制造方法及其用途公开(公告)号：US20040048786A1
公开(公告)日：2004-03-11
申请号：US10600548
申请日：2003-06-20
IPC分类号： A61K038/14 , A61K031/704 , A61K031/496
CPC分类号： A61L27/56 , A61L27/54 , A61L2300/406
摘要： The invention describes an antibiotic coating for porous bodies and its use. Into the porous system of non-metallic porous bodies and of metallic porous bodies, a coating made of at least one antibiotic salt that is hardly soluble in water or in an aqueous environment from the group of the netilmicin laurate, the netilmicin myristate, the netilmicin dodecyl sulfate, the sisomicin laurate, the sisomicin myristate, the sisomicin dodecyl sulfate, the gentamicin laurate, the gentamicin myristate, the clindamycin laurate, the amikacin laurate, the amikacin myristate, the amikacin dodecyl sulfate, the kanamycin laurate, the kanamycin myristate, the kanamycin dodecyl sulfate, the tobramycin laurate, the tobramycin myristate, the tobramycin dodecyl sulfate, the ciprofloxacin myristate, the vancomycin dodecyl sulfate, the vancomycin laurate, the vancomycin myristate, the vancomycin teicoplanin and the clindamycin teicoplanin is introduced. The antibiotically coated, porous bodies are used as implants.
摘要翻译： 本发明描述了用于多孔体的抗生素涂层及其用途。 在非金属多孔体和金属多孔体的多孔体系中，由至少一种几乎不溶于水或在水性环境中的抗生素盐制成的涂层，所述抗生素盐来自于来自月桂酸西拉米星的组合，肉豆蔻酸甜菜豆素， 十二烷基硫酸酯，月桂酸西索米星，肉豆蔻酸西索米星，十二烷基硫酸锡，庆大霉素月桂酸酯，肉豆蔻酸庆大霉素，月桂酸克林霉素，月桂酸阿米卡星，肉豆蔻酸阿米卡星，阿米卡星十二烷基硫酸盐，卡那霉素月桂酸酯，肉豆蔻酸卡那霉素 卡那霉素十二烷基硫酸盐，妥布霉素月桂酸酯，妥布霉素十四烷基硫酸盐，妥布霉素十二烷基硫酸盐，环丙沙星肉豆蔻酸盐，万古霉素十二烷基硫酸盐，万古霉素月桂酸盐，万古霉素肉豆蔻酸盐，万古霉素替考拉宁和克林霉素替考拉宁。 抗菌涂层的多孔体用作植入物。
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公开(公告)号：US20020192279A1
公开(公告)日：2002-12-19
申请号：US10100843
申请日：2002-03-19
IPC分类号： A61K031/7008 , A61K031/665 , A61K009/20
CPC分类号： A61K31/7036 , A61K9/2009 , A61K31/00
摘要： A method for producing antibiotic composites is described, which is characterized in that a salt, which can be subjected to plastic deformation and which consists of at least one cationic component of a protonated antibiotics base from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics and of at least one anionic components from the group of organic sulfates and/or organic sulfonates and/or fatty acid esters, is used as a binding agent for the fixation of inorganic composite components and/or possibly organic composite components and possibly for the molding of the composites while adding water, especially through pressing, extrusion, rolling, calendering and grinding processes.
摘要翻译： 描述了一种生产抗生素复合材料的方法，其特征在于可以进行塑性变形的盐，其由至少一种由氨基糖苷类抗生素组成的质子化抗生素碱的阳离子组分，氯胺素抗生素和 使用四环素抗生素和来自有机硫酸盐和/或有机磺酸盐和/或脂肪酸酯基团的至少一种阴离子组分作为固定无机复合组分和/或可能的有机复合组分的粘合剂，并且可能用于 同时加入水，特别是通过压制，挤出，轧制，压延和研磨加工而成型。
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