公开(公告)号：US06787525B1

公开(公告)日：2004-09-07

申请号：US09856165

申请日：2001-09-12

申请人： Herbert Schott ,  Peter Stephan Ludwig

发明人： Herbert Schott ,  Peter Stephan Ludwig

IPC分类号： A61K3170

CPC分类号： C07H19/06 ,  C07H19/16 ,  C07H19/207

摘要： The invention relates to glyceryl nucleotides of the formula Ia in which a) one of the radicals A1, A2 and A3 is a hydrogen atom or a radical selected from hydroxyl, mercapto, alkyl, alkenyl, polyoxyalkenyl, aryl, acyl, alkyloxy, alkenyloxy, polyoxyalkenyloxy, acyloxy, aryloxy, alkylthio, alkenylthio, acylthio and arylthio, where the alkyl, alkenyl and acyl radicals are optionally substituted by from 1 to 3 aryl radicals; and b1) two of the remaining radicals A1, A2 and A3 are two nucleoside groups which are different from each other; or b2) one of the remaining radicals A1, A2 and A3 is a nucleoside group and the other of the remaining radicals is a hydroxycarbonyl group, where at least one of the nucleoside groups is not a naturally occurring nucleoside group; to processes for preparing these compounds, to pharmaceutical remedies which comprise these compounds, and to the use of these compounds for treating cancer diseases and infectious diseases.

摘要翻译： 本发明涉及式Iain的甘油基核苷酸，其中a 1，A 2和A 3之一是氢原子或选自羟基，巯基，烷基，烯基，聚氧乙烯基，芳基 酰基，烷氧基，烯氧基，聚氧乙烯氧基，酰氧基，芳氧基，烷硫基，烯硫基，酰硫基和芳硫基，其中烷基，链烯基和酰基任选被1至3个芳基取代; 和b1）剩余的基团A 1，A 2和A 3中的两个是彼此不同的两个核苷酸基团; orb2）剩余基团A 1，A 2和A 3中的一个是核苷基团，剩余的基团中的另一个是羟基羰基，其中至少一个核苷基团不是天然存在的 核苷类;制备这些化合物的方法，包含这些化合物的药物治疗剂以及这些化合物用于治疗癌症疾病和感染性疾病的用途。