公开(公告)号：US20060003939A1

公开(公告)日：2006-01-05

申请号：US10431638

申请日：2003-05-08

申请人： Hermann Steller ,  Hyung Ryoo ,  Aaron Ciechanover ,  Hedva Gonen

发明人： Hermann Steller ,  Hyung Ryoo ,  Aaron Ciechanover ,  Hedva Gonen

IPC分类号： A61K38/10 ,  C07K7/08

CPC分类号： C07K14/4747 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C12N2799/026

摘要： The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.

公开(公告)号：US20060058229A1

公开(公告)日：2006-03-16

申请号：US10513465

申请日：2003-05-08

申请人： Hermann Steller ,  Hyung Ryoo ,  Aaron Ciechanover ,  Hedva Gonen

发明人： Hermann Steller ,  Hyung Ryoo ,  Aaron Ciechanover ,  Hedva Gonen

IPC分类号： A61K38/17

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention provides novel peptides, nucleic acids, compounds, compositions and methods for regulating apoptosis, and screening methods for identifying same. Regulation of apoptosis is mediated via IAPi-derived proteins, peptide fragments thereof, and nucleic acids encoding same, stimulating/accelerating or downmodulating/suppressing apoptosis. For stimulation/acceleration of apoptosis, the IAPi-derived proteins or peptide fragments thereof comprise RHG and Trp-box amino acid consensus sequences. Stimulation/acceleration results in self-ubiquitination and auto-degradation of an IAP. For downmodulation/suppression of apoptosis, IAPi-derived proteins or peptide fragments thereof comprising either RHG or Trp-box amino acid consensus sequences, or both, failing to stimulate or suppressing self-ubiquitination and auto-degradation of an IAP, result in suppression of apoptosis.