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1.
公开(公告)号:US5627288A
公开(公告)日:1997-05-06
申请号:US613868
申请日:1996-03-11
IPC分类号: B01J27/122 , B01J31/04 , C07B61/00 , C07C51/04 , C07C59/76 , C07C67/14 , C07C69/738 , C07D307/36 , C07D307/58 , C07D307/88
CPC分类号: C07C69/738 , C07C59/76 , C07D307/36 , C07D307/58
摘要: Disclosed are 3,7-dimethyl-4-oxo-7-octenoic acid and its alkyl esters which are intermediates for producing a fragrance, rosefuran and which are represented by: ##STR1## where R is H or a lower alkyl. The compounds [1] are obtained by reacting 2-methyl-3-alkoxycarbonylpropionic acid halide and 3-methyl-3-butenylmagnesium halide. The octenoic acid [1] is treated with acetic anhydride under heat in the presence of an acidic catalyst to give 3,7-dimethyl-2,6-octadien-4-olide. The olide is reduced in an ordinary manner to give rosefuran.
摘要翻译: 公开了3,7-二甲基-4-氧代-7-辛烯酸及其烷基酯,其是用于生产香料,呋喃丹的中间体,其由下式表示:其中R是H或低级烷基。 化合物[1]是通过2-甲基-3-烷氧基羰基丙酸卤化物和3-甲基-3-丁烯基卤化镁反应得到的。 在酸性催化剂存在下,加热下用乙酸酐处理辛烯酸[1],得到3,7-二甲基-2,6-辛二烯-4-醇。 以常规方式还原橄榄,得到呋喃丹。