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公开(公告)号：US07723350B2
公开(公告)日：2010-05-25
申请号：US12142899
申请日：2008-06-20
IPC分类号： A61K31/438 , C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US08431590B2
公开(公告)日：2013-04-30
申请号：US12665335
申请日：2008-06-20
申请人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
发明人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
IPC分类号： C07D401/04 , C07D401/14 , A61K31/438 , A61K31/4439
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US20080318990A1
公开(公告)日：2008-12-25
申请号：US12142899
申请日：2008-06-20
IPC分类号： A61K31/438 , C07D471/10 , A61P25/28 , A61P3/10
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US20110034499A1
公开(公告)日：2011-02-10
申请号：US12665335
申请日：2008-06-20
申请人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
发明人： Brian W. Budzik , Hilary Schenck Eidam , Ryan Michael Fox , Krista B. Goodman , Dimitar B. Gotchev , Pamela A. Haile , Terry Vincent Hughes , Ronggang Liu , Nathan A. Miller , Tamara Ann Miskowski , Clark A. Sehon , Andrew Q. Viet , Gren Z. Wang , Jing Zhang
IPC分类号： A61K31/438 , C07D471/10 , A61P9/10 , A61P29/00 , A61P31/16 , A61P3/00 , A61P3/10 , A61P25/00 , A61P11/06 , A61P13/12 , A61P9/04 , A61P25/28 , A61P1/00 , A61P15/00
CPC分类号： C07D471/10
摘要： The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.
摘要翻译： 本发明涉及下式的化合物：其中R 1 -R 6，R 10，Y，n，m，p和q如本文所定义。 本发明的化合物和组合物可用于治疗与过度表达CCR2相关的疾病。
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公开(公告)号：US20130023532A1
公开(公告)日：2013-01-24
申请号：US13637419
申请日：2011-03-26
申请人： Linda N. Casillas , Subhas J. Chakravorty , Adam Kenneth Charnley , Pamela A. Haile , Terry Vincent Hughes , Jae U. Jeong , Jianxing Kang , Ami Lakdawala Shah , Lara Kathryn Leister , Robert W. Marquis, JR. , Nathan Andrew Miller , Daniel J. Price , Clark A. Sehon , Gren Z. Wang , Daohua Zhang , Patrick Eidam
发明人： Linda N. Casillas , Subhas J. Chakravorty , Adam Kenneth Charnley , Pamela A. Haile , Terry Vincent Hughes , Jae U. Jeong , Jianxing Kang , Ami Lakdawala Shah , Lara Kathryn Leister , Robert W. Marquis, JR. , Nathan Andrew Miller , Daniel J. Price , Clark A. Sehon , Gren Z. Wang , Daohua Zhang , Patrick Eidam
IPC分类号： A61K31/5377 , A61K31/437 , A61K31/454 , C07D409/14 , C07D471/04 , C07D401/12 , C07D405/14 , A61K31/506 , C07D403/12
CPC分类号： C07D403/12 , C07D409/14 , C07D471/04
摘要： Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物或其盐，其中A，n，R 1，R 1A和R 2如本文所定义，及其制备和使用方法。
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公开(公告)号：US20130023534A1
公开(公告)日：2013-01-24
申请号：US13637430
申请日：2011-03-26
申请人： Linda N. Casillas , Subhas J. Chakravorty , Patrick Eidam , Pamela A. Haile , Terry Vincent Hughes , Ami Lakdawala Shah , Lara Kathryn Leister , Nathan Andrew Miller , Attiq Rahman , Clark A. Sehon , Gren Z. Wang , Daohua Zhang
发明人： Linda N. Casillas , Subhas J. Chakravorty , Patrick Eidam , Pamela A. Haile , Terry Vincent Hughes , Ami Lakdawala Shah , Lara Kathryn Leister , Nathan Andrew Miller , Attiq Rahman , Clark A. Sehon , Gren Z. Wang , Daohua Zhang
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/14 , C07D409/14 , C07D417/14 , C07D401/12 , C07D413/12 , A61K31/506 , C07D405/14
CPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds having the formula (I): wherein Z, n, R1, R1A, R3, R4, and R5 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有式（I）的化合物：其中Z，n，R 1，R 1A，R 3，R 4和R 5如本文所定义，及其制备和使用方法。
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公开(公告)号：US20120041024A1
公开(公告)日：2012-02-16
申请号：US13206706
申请日：2011-08-10
IPC分类号： A61K31/4709 , A61P27/02 , A61P17/00 , A61P1/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P1/04 , C07D401/12 , A61P11/00
CPC分类号： C07D401/12 , C07D405/14
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3, R4 and R5 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物：其中R1，R2，R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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