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    Process for the manufacture of 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts
    10.
    发明授权
    Process for the manufacture of 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts 失效
    1-取代-4-氟-1,4-二氮杂双环[2.2.2]辛烷盐的制备方法

    公开(公告)号：US5631372A

    公开(公告)日：1997-05-20

    申请号：US642994

    申请日：1996-05-06

    申请人： Andrew J. Poss ,  George A. Shia ,  Dennis M. Lavery

    发明人： Andrew J. Poss ,  George A. Shia ,  Dennis M. Lavery

    IPC分类号： C07D487/08 ,  C07D247/00 ,  C07D243/14 ,  C07D245/04 ,  C07F9/06

    CPC分类号： C07D487/08

    摘要： A process for producing 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane salts having the formula ##STR1## wherein the Z substituent is OH, OR, OC(O)R, SO.sub.3, SO.sub.2 R, NO.sub.2, NO, or PO(OR).sub.2, wherein R is an aryl or C.sub.1 -C.sub.8 alkyl group; n is 0, 1 or 2; each of R.sub.1, R.sub.2, R.sub.3, P.sub.4 and R.sub.5 independently represent hydrogen, C.sub.1 to C.sub.8 alkyl, or aryl 1-substituted-1,4-diazoniabicyclo[2.2.2]octane or 1,4-diazoniabicyclo[2.2.2]octane mono-N-oxide is reacted to attach the Z group and then the result is reacted with molecular fluorine in the presence of a solvent that substantially does not react with fluorine and a fluoride scavenger that results in an X counter ion. These compounds are useful as fluorinating agents for the introduction of fluorine into organic compounds.

    摘要翻译： 一种制备具有式“IMAGE”的1-取代-4-氟-1,4-二氮鎓双环[2.2.2]辛烷盐的方法，其中Z取代基是OH，OR，OC（O）R，SO 3，SO 2 R，NO 2 ，NO或PO（OR）2，其中R是芳基或C 1 -C 8烷基; n为0,1或2; R1，R2，R3，P4和R5各自独立地表示氢，C1至C8烷基或芳基1-取代-1,4-二氮鎓双环[2.2.2]辛烷或1,4-二氮鎓双环[2.2.2]辛烷单 N-氧化物反应以连接Z基团，然后在基本上不与氟反应的溶剂和导致X抗衡离子的氟化物清除剂的存在下，使分子氟与分子氟反应。 这些化合物可用作将氟引入有机化合物中的氟化剂。