公开(公告)号：US06217875B1

公开(公告)日：2001-04-17

申请号：US09053064

申请日：1998-04-01

申请人： Hiromichi Murai ,  Tadashi Okada ,  Hiroyo Yamamoto

发明人： Hiromichi Murai ,  Tadashi Okada ,  Hiroyo Yamamoto

IPC分类号： A61K3578

CPC分类号： A61K36/535 ,  A61K2300/00

摘要： Novel inhibitors of the enzyme action of lipoxygenase, especially 5-lipoxygenase and 12-lipoxygenase that are derived from the extraction of the seeds of the perilla (crispa) or perilla (frutescens) plant. These inhibitors are suitably extracted from these seeds using alcohol, preferably ethanol, to form an extract or more preferably to further extract the alcoholic extract with ethyl acetate and water to partition the active inhibitors to the ethyl acetate. The particularly preferred inhibitors are luteolin and chrysoeriol.

摘要翻译： 脂肪氧合酶的酶作用的新型抑制剂，特别是从提取紫苏（紫菜）或紫苏（frutescens）植物的种子得到的5-脂氧合酶和12-脂氧合酶。 使用醇，优选乙醇，适当地从这些种子中提取这些抑制剂以形成提取物，或更优选用乙酸乙酯和水进一步提取醇提取物，以将活性抑制剂分配至乙酸乙酯。 特别优选的抑制剂是木犀草素和氯菊酯。