公开(公告)号：US20060094869A1

公开(公告)日：2006-05-04

申请号：US11287212

申请日：2005-11-28

申请人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

发明人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

IPC分类号： C07H19/04

CPC分类号： C07H19/10 ,  C07H19/00 ,  C07H19/20

摘要： A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.

摘要翻译： 通过使1-磷酸化糖衍生物的异头混合物进行磷酸化和异构化同时结晶异构体之一以置换平衡来选择性地制备所需的异构体。 此外，使用核苷磷酰化酶的作用，由所得的1-磷酸化糖衍生物和具有改善的立体选择性和较高产率的碱制备核苷。 该方法是用于制备1-磷酸化糖衍生物和核苷的前体选择性方法。

公开(公告)号：US07038039B2

公开(公告)日：2006-05-02

申请号：US09958305

申请日：2001-02-13

申请人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

发明人： Hironori Komatsu ,  Hirokazu Awano ,  Nobuyuki Fukazawa ,  Kiyoshi Ito ,  Ichirou Ikeda ,  Tadashi Araki ,  Takeshi Nakamura ,  Tamotsu Asano ,  Junya Fujiwara ,  Tomoyuki Ando ,  Katsutoshi Tsuchiya ,  Kyoko Maruyama ,  Hideki Umetani ,  Takahiro Yamauchi ,  Hitoki Miyake

IPC分类号： A61K31/665 ,  A61K31/7024 ,  C07F9/6544

CPC分类号： C07H19/10 ,  C07H19/00 ,  C07H19/20

摘要： A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.