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    Condensed purine derivatives
    1.
    发明授权
    Condensed purine derivatives 失效
    凝血嘌呤衍生物

    公开(公告)号：US06306847B1

    公开(公告)日：2001-10-23

    申请号：US09090936

    申请日：1998-06-05

    申请人： Hiroshi Tsumuki ,  Mayumi Saki ,  Hiromi Nonaka ,  Michio Ichimura ,  Junichi Shimada ,  Fumio Suzuki ,  Shunji Ichikawa ,  Nobuo Kosaka

    发明人： Hiroshi Tsumuki ,  Mayumi Saki ,  Hiromi Nonaka ,  Michio Ichimura ,  Junichi Shimada ,  Fumio Suzuki ,  Shunji Ichikawa ,  Nobuo Kosaka

    IPC分类号： C07D48714

    CPC分类号： C07D487/14

    摘要： The present invention provides condensed purine derivatives or pharmacologically acceptable salts thereof exhibiting adenosine A3 acceptor antagonising activity, and having an antiasthmatic action, a bronchodilator action, an antiantiitching action, etc., and represented by the following formula (I): (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R2 represents hydrogen, lower alkyl, alicyclic alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; R3 represents hydrogen, lower alkyl, or substituted or unsubstituted aralkyl; X1 and X2 are the same or different and each represents hydrogen, lower alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl; and n represents an integer of 0 to 3).

    摘要翻译： 本发明提供具有腺苷A3受体拮抗活性的缩合嘌呤衍生物或其药理学上可接受的盐，并具有抗哮喘作用，支气管扩张剂作用，抗脱除作用等，并由下式（I）表示:(其中R1表示 取代或未取代的芳基或取代或未取代的芳族杂环基; R 2表示氢，低级烷基，脂环族烷基，取代或未取代的芳烷基，取代或未取代的芳基或取代或未取代的芳族杂环基; R 3表示氢，低级烷基或 取代或未取代的芳烷基; X 1和X 2相同或不同，各自表示氢，低级烷基，取代或未取代的芳烷基或取代或未取代的芳基; n表示0〜3的整数。

    Preventive and/or therapeutic drugs for asthma
    3.
    发明申请
    Preventive and/or therapeutic drugs for asthma 审中-公开
    用于哮喘的预防和/或治疗药物

    公开(公告)号：US20060239999A1

    公开(公告)日：2006-10-26

    申请号：US10525326

    申请日：2003-08-22

    申请人： Mayumi Saki ,  Hiromi Nonaka ,  Hiromasa Miyaji ,  Naoko Hiura ,  Haruhiko Manabe ,  Tsotomu Matsumura ,  Hitoshi Arai ,  Katsutoshi Sasaki ,  Cjoei Kobatake ,  Kyoichiro Iida ,  Takeshi Kuboyama

    发明人： Mayumi Saki ,  Hiromi Nonaka ,  Hiromasa Miyaji ,  Naoko Hiura ,  Haruhiko Manabe ,  Tsotomu Matsumura ,  Hitoshi Arai ,  Katsutoshi Sasaki ,  Cjoei Kobatake ,  Kyoichiro Iida ,  Takeshi Kuboyama

    IPC分类号： A61K48/00 ,  A61K39/395 ,  A61K31/55

    CPC分类号： A61K31/519 ,  A61K31/55 ,  A61K31/7088 ,  C07D403/06

    摘要： The present invention provides an agent for prevention and/or treatment of asthma comprising a substance capable of suppressing the function involved in signal transduction of GPR4 as an active ingredient. It also provides an agent for prevention and/or treatment of asthma which comprises a nitrogen-containing tricyclic compound represented by the formula (I) or a quaternary ammonium salt thereof, or a pharmaceutically acceptable salt thereof; [wherein R1 represents a substituted or unsubstituted lower alkyl, or the like; R2 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; R3 and R4 are the same or different and each represents hydrogen, lower alkyl, or the like; n represents 0 or 1; X represents —(CH2)2—, or the like; and Y represents the formula (II) (wherein W represents CH or a nitrogen atom; Z1 and Z2 are the same or different and each represents hydrogen, a substituted or unsubstituted lower alkyl, or the like; and Z3 represents hydrogen, a substituted or unsubstituted lower alkyl, or the like)] as an active ingredient.

    摘要翻译： 本发明提供了用于预防和/或治疗哮喘的药剂，其包含能够抑制作为活性成分的GPR4的信号转导所涉及的功能的物质。 它还提供了一种预防和/或治疗哮喘的药剂，其包含由式（I）表示的含氮三环化合物或其季铵盐或其药学上可接受的盐; [其中R 1表示取代或未取代的低级烷基等; R 2表示氢，取代或未取代的低级烷基等; R 3和R 4相同或不同，各自表示氢，低级烷基等; n表示0或1; X表示 - （CH 2 2）2 - 等; Y表示式（II）（其中W表示CH或氮原子; Z 1和Z 2相同或不同，各自表示氢，取代或 未取代的低级烷基等; Z 3表示氢，取代或未取代的低级烷基等）作为活性成分。