公开(公告)号：US4709032A

公开(公告)日：1987-11-24

申请号：US919774

申请日：1986-10-17

申请人： Hiroyoshi Hidaka ,  Takanori Sone

发明人： Hiroyoshi Hidaka ,  Takanori Sone

IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P9/08 ,  A61P9/12 ,  C07D217/02 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D217/02 ,  Y02P20/55

摘要： This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group;R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.

公开(公告)号：US4678783A

公开(公告)日：1987-07-07

申请号：US813973

申请日：1985-12-27

申请人： Hiroyoshi Hidaka ,  Takanori Sone

发明人： Hiroyoshi Hidaka ,  Takanori Sone

IPC分类号： C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D401/12 ,  A61K31/495 ,  A61K31/47

CPC分类号： C07D401/12 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24

摘要： An isoquinolinesulfonyl compound represented by the formula (I): ##STR1## wherein R.sup.1 : H, Cl, OHA : unsubstituted or substituted ethylene or alkyleneR.sup.2, R.sup.3 : H, alkyl, jointly forming unsubstituted or substituted ethylene or trimethyleneR.sup.4 : H, alkyl, amidinoor an acid salt thereof.They can be prepared, for example, by converting 1-R.sup.1 substituted-5-isoquinolinesulfonic acid to the corresponding sulfonyl chloride and subsequently reacting the chloride with a compound of formula ##STR2## They can be advantageously utilized as vasodilator, cerebral circulation ameliorator, antihypertensive agent and drugs for prevention and treatment of various circulatory organ diseases.

摘要翻译： 由式（I）表示的异喹啉磺酰化合物：其中R1：H，Cl，OHA：未取代或取代的亚乙基或亚烷基R2，R3：H，烷基，共同形成未取代或取代的乙烯或三亚甲基R4 ：H，烷基，脒基或其酸式盐。 它们可以例如通过将1-R1取代-5-异喹啉磺酸转化成相应的磺酰氯并随后使氯化物与式的化合物反应来制备。它们可以有利地用作血管扩张剂，脑循环改善剂，抗高血压药 用于预防和治疗各种循环器官疾病的药剂和药物。

公开(公告)号：US4510307A

公开(公告)日：1985-04-09

申请号：US293192

申请日：1981-08-17

申请人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara ,  Seiji Takagi ,  Kiyohide Sako

发明人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara ,  Seiji Takagi ,  Kiyohide Sako

IPC分类号： C07D239/86 ,  C07D239/88 ,  C07D239/94 ,  C07D265/00 ,  C07D247/00 ,  C07D403/00

CPC分类号： C07D239/94 ,  C07D239/86 ,  C07D239/88 ,  Y10S514/929

摘要： A 6-quinazolinesulfonyl derivative of Formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1-12 alkyl group:R.sub.2 is a hydrogen atom, a C.sub.1-12 alkyl group, a C.sub.4-10 cycloalkyl group, an aryl group or an aralkyl group; andR.sub.1 and R.sub.2 may be linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring together with the adjacent nitrogen atom; andR.sub.3 is a ##STR2## group wherein R.sub.4 is a C.sub.1-8 alkyl group; a --HN(CH.sub.2).sub.n NH.sub.2 group wherein n is an integer of 2 to 10; or a ##STR3## group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

摘要翻译： 式（I）的6-喹唑啉磺酰基衍生物：其中R1是氢原子或C1-12烷基：R2是氢原子，C1-12烷基，C4-10环烷基 ，芳基或芳烷基; R1和R2可以直接或通过氧原子连接，与相邻的氮原子一起形成5-至7-元杂环; 并且R 3是一个基团，其中R 4是C 1-8烷基; 其中n为2〜10的整数的-HN（CH 2）n NH 2基; 或组 及其药学上可接受的盐; 及其制备方法。 本发明的化合物对于血管平滑肌具有松弛作用，并且可用作血管扩张剂和低血压。

公开(公告)号：US4634770A

公开(公告)日：1987-01-06

申请号：US548722

申请日：1983-11-04

申请人： Hiroyoshi Hidaka ,  Takanori Sone

发明人： Hiroyoshi Hidaka ,  Takanori Sone

IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P9/08 ,  A61P9/12 ,  C07D217/02 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D217/02 ,  Y02P20/55

摘要： This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group;R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.

摘要翻译： 本发明涉及式（I）的新型异喹啉磺酰胺衍生物：其中A是C0-10亚烷基或具有C1-10烷基的C0-10亚烷基，苯基，取代苯基 基团或苯基烷基; R1和R2各自为氢原子; 或R 1和R 2直接连接形成未被取代或被C 1-4烷基取代的亚乙基; R 3和R 4各自为氢原子，C 1-6烷基或直接连接以形成C 2-6亚烷基; 及其药学上可接受的酸加成盐及其制备方法。 异喹啉衍生物具有血管平滑肌的松弛作用和增加血流量的作用，可用作血管扩张剂和低血压。

公开(公告)号：US4560755A

公开(公告)日：1985-12-24

申请号：US572419

申请日：1984-01-20

申请人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara

发明人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara

IPC分类号： C07D217/02 ,  C07D401/12 ,  A61K31/495

CPC分类号： C07D217/02

摘要： A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one;m and n each is an integer of one to nine;m+n is an integer of at least one;R.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; orR.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group;R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; or the ##STR2## wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR3## wherein R.sub.7 is a C.sub.1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

公开(公告)号：US4525589A

公开(公告)日：1985-06-25

申请号：US572418

申请日：1984-01-20

申请人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara

发明人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara

IPC分类号： C07D217/02 ,  C07D413/12

CPC分类号： C07D217/02

摘要： A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one;m and n each is an integer of one to nine;m+n is an integer of at least oneR.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; orR.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group;R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; orthe ##STR2## group is a ##STR3## group wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR4## group wherein R.sub.7 is a C.sub.1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

公开(公告)号：US4456757A

公开(公告)日：1984-06-26

申请号：US357770

申请日：1982-03-12

申请人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara

发明人： Hiroyoshi Hidaka ,  Takanori Sone ,  Yasuharu Sasaki ,  Taisuke Sugihara

IPC分类号： C07D217/02 ,  A61K31/47 ,  C07D401/12 ,  C07D413/12

CPC分类号： C07D217/02

摘要： A 5-isoquinolinesulfonyl derivative of Formula (I): ##STR1## wherein l is zero or one;m and n each is an integer of one to nine;m+n is an integer of at least one;R.sub.1 is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group or an aryl group; orR.sub.2 and R.sub.3 each is a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.5-6 cycloalkyl group, an aryl group or an aralkyl group;R.sub.2 and R.sub.3 are C.sub.1-6 alkylene groups and linked directly or through an oxygen atom to form a 5- to 7-membered heterocyclic ring with the adjacent nitrogen atom; orthe ##STR2## group is a ##STR3## group wherein R.sub.4 and R.sub.5 each is a hydrogen atom, a C.sub.1-10 alkyl group, an aryl group or an aralkyl group and R.sub.6 is a hydrogen atom, a C.sub.1-10 alkyl group, and aryl group, an aralkyl group, a benzoyl group, a cinnamyl group, a cinnamoyl group, a furoyl group or a ##STR4## group wherein R.sub.7 is a C.sub.1-8 alkyl group; and the pharmaceutically acceptable salt thereof; and a process for the preparation thereof. The compounds of this invention have a relaxatory action for vascular smooth muscle and are useful as a vasodilator and a hypotensor.

摘要翻译： 式（I）的5-异喹啉磺酰基衍生物：其中I为0或1; m和n各自为1至9的整数; m + n是至少一个的整数; R1是氢原子，C1-10烷基，C5-6环烷基或芳基; 或R 2和R 3各自为氢原子，C 1-10烷基，C 5-6环烷基，芳基或芳烷基; R2和R3是C1-6亚烷基，直接或通过氧原子与相邻氮原子形成5至7元杂环; 或者组是一个基团，其中R4和R5各自为氢原子，C1-10烷基，芳基或芳烷基，R6为氢原子，C1-10烷基， 芳基，芳烷基，苯甲酰基，肉桂基，肉桂酰基，糠酰基或ⅩⅩⅧ基，其中R 7为C 1-8烷基; 及其药学上可接受的盐; 及其制备方法。 本发明的化合物对于血管平滑肌具有松弛作用，并且可用作血管扩张剂和低血压。

公开(公告)号：US20050281700A1

公开(公告)日：2005-12-22

申请号：US11057226

申请日：2005-02-15

申请人： Kunihiko Egawa ,  Yoshio Kubo ,  Takayuki Nagai ,  Takanori Sone ,  Kiyoshi Hiramoto ,  Masayoshi Wake

发明人： Kunihiko Egawa ,  Yoshio Kubo ,  Takayuki Nagai ,  Takanori Sone ,  Kiyoshi Hiramoto ,  Masayoshi Wake

IPC分类号： H01K3/02 ,  H01L39/24

CPC分类号： H01L39/2409 ,  Y10T29/49014 ,  Y10T29/49117

摘要： A method of producing Nb3Sn superconducting wire, including the steps of: preparing a plurality of Sn modules obtained by burying Sn-based metal cores in a Cu-based metal matrix and a plurality of Nb modules obtained by burying Nb-based metal filaments in a Cu-based metal matrix; bundling the Nb modules and the Sn modules such that the Nb modules surround the Sn modules and obtaining an assembly; inserting the assembly in a tubular member of Cu-based metal which internally comprises tube-like shaped Ta-based metal or Nb-based metal which serves as a diffusion barrier and obtaining a composite; drawing the composite; and heat-treating the composite.

摘要翻译： 一种制造Nb 3 Sn超导线的方法，包括以下步骤：制备通过将Cu基金属芯埋入Cu基金属基体中而获得的多个Sn模块和多个Nb模块 通过将Nb基金属细丝埋入Cu基金属基体中; 捆绑Nb模块和Sn模块，使得Nb模块围绕Sn模块并获得组件; 将组件插入Cu基金属的管状构件中，其内部包括用作扩散阻挡层并获得复合材料的管状Ta基金属或Nb基金属; 绘制复合材料; 并对该复合材料进行热处理。

公开(公告)号：US4474964A

公开(公告)日：1984-10-02

申请号：US569524

申请日：1984-01-09

申请人： Tadayuki Ibuki ,  Taisuke Sugihara ,  Hiromu Kawakubo ,  Takanori Sone

发明人： Tadayuki Ibuki ,  Taisuke Sugihara ,  Hiromu Kawakubo ,  Takanori Sone

IPC分类号： C07D231/56 ,  C07D295/092 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D231/56 ,  C07D295/088

摘要： A compound of the formula (I): ##STR1## wherein W.sub.1 is a hydrogen atom or a ##STR2## group wherein Y is a C.sub.1-6 alkylene group or a C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.1 and R.sub.2 each independently is a hydrogen atom or a C.sub.1-6 alkyl group and R.sub.1 and R.sub.2 may form a C.sub.4-6 heterocyclic ring or a nitrogen-containing C.sub.4-6 heterocyclic ring together with the adjacent nitrogen atom and the C.sub.4-6 heterocyclic rings may have at least one C.sub.1-6 alkyl group, hydroxyl group or halogen atom;W.sub.2 is a hydrogen atom or a ##STR3## group wherein Z is a C.sub.1-6 alkylene group or a C.sub.1-6 alkylene group having a C.sub.1-6 alkyl group substituent; and R.sub.3 and R.sub.4 each independently is a hydrogen atom or a C.sub.1-6 alkyl group and R.sub.3 and R.sub.4 may form a C.sub.4-6 heterocyclic ring or a nitrogen-containing C.sub.4-6 heterocyclic ring together with the adjacent nitrogen atom and the C.sub.4-6 heterocyclic rings may have at least one C.sub.1-6 alkyl group, hydroxyl group or halogen atom;when W.sub.1 is a hydrogen atom, W.sub.2 is the ##STR4## group; and when W.sub.2 is a hydrogen atom, W.sub.1 is the ##STR5## group; and the pharmaceutically acceptable acid addition salt thereof having antiinflammatory, analgesic and digestive tract ulcer suppressing activity.

摘要翻译： 式（I）的化合物：其中W1是氢原子或其中Y是C1-6亚烷基或具有C1-6烷基的C1-6亚烷基的基团 取代基; 并且R 1和R 2各自独立地为氢原子或C 1-6烷基，并且R 1和R 2可以与相邻的氮原子一起形成C 4-6杂环或含氮的C 4-6杂环，并且C 4-6 杂环可以具有至少一个C 1-6烷基，羟基或卤素原子; W2是氢原子或其中Z是C1-6亚烷基或具有C1-6烷基取代基的C1-6亚烷基的基团; 并且R 3和R 4各自独立地为氢原子或C 1-6烷基，并且R 3和R 4可以与相邻的氮原子一起形成C 4-6杂环或含氮的C 4-6杂环，且C 4-6 杂环可以具有至少一个C 1-6烷基，羟基或卤素原子; 当W1是氢原子时，W2是组; 当W2是氢原子时，W1是组; 和其药学上可接受的酸加成盐具有抗炎，止痛和消化道溃疡抑制活性。

公开(公告)号：US4417047A

公开(公告)日：1983-11-22

申请号：US350805

申请日：1982-02-22

申请人： Chisei Shibuya ,  Masahiro Murakami ,  Masateru Kobayashi ,  Takanori Sone

发明人： Chisei Shibuya ,  Masahiro Murakami ,  Masateru Kobayashi ,  Takanori Sone

IPC分类号： C07D257/04 ,  C07D501/36 ,  C07D501/04 ,  C07D501/06

CPC分类号： C07D257/04

摘要： This invention relates to a tetrazole-5-thiol ester having D-configuration of the formula, ##STR1## a process for the preparation of the thiol ester and a process for the preparation of cefamandole using the thiol ester.

摘要翻译： 本发明涉及具有下式的D构型的四唑-5-硫醇酯：制备硫羟酸酯的方法和使用硫羟酸酯制备头孢丹多的方法。