公开(公告)号：US20060173009A1

公开(公告)日：2006-08-03

申请号：US10563107

申请日：2004-06-30

申请人： Hiroyuki Kanoh ,  Koichiro Takahashi ,  Hiromi Nara ,  Tatsuhiko Yamanoi ,  Shinji Fukushima ,  Ryo Naito ,  Susumu Igarashi

发明人： Hiroyuki Kanoh ,  Koichiro Takahashi ,  Hiromi Nara ,  Tatsuhiko Yamanoi ,  Shinji Fukushima ,  Ryo Naito ,  Susumu Igarashi

IPC分类号： A61K31/503

CPC分类号： A61K31/5025 ,  A61K31/662 ,  A61K31/663 ,  A61K2300/00

摘要： Osteoporosis and the like metabolic bone diseases have a high frequency of causing lumbago and the like pains and bone fracture, due to lowering of the bone strength caused by the reduction of bone mass. Accordingly, great concern has been directed toward the creation of a drug which can increase the bone mass and bone strength by controlling the whole bone metabolism. The pharmaceutical composition or combination product of the invention comprising a non-living body-derived non-peptide osteoblast differentiation promoting compound and a bisphosphonate having a bone resorption inhibitory action is useful as a bone mass increasing inducer which can increase the bone mass and/or bone strength by controlling the bone metabolism.

摘要翻译： 骨质疏松等代谢性骨疾病由于骨质量下降引起的骨强度降低，频繁地引起腰痛等骨折。 因此，非常关注通过控制整个骨代谢来增加骨量和骨强度的药物的产生。 包含非生物体衍生的非肽成骨细胞分化促进化合物和具有骨吸收抑制作用的二膦酸盐的本发明的药物组合物或组合产品可用作骨质量增加诱导剂，其可以增加骨量和/或 通过控制骨骼代谢的骨骼力量。