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1.发明授权4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof 有权4,4-二氟-1,2,3,4-四氢-5H-1-苯并氮杂衍生物或其盐公开(公告)号：US07807664B2
公开(公告)日：2010-10-05
申请号：US11598732
申请日：2006-11-14
IPC分类号： A61P7/12 , A61K31/55 , C07D223/16
CPC分类号： C07D401/06 , C07D223/16
摘要： A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided.
摘要翻译： 提供了可用作治疗或预防夜尿和/或尿崩症的药剂的新型的4,4-二氟-1,2,3,4-四氢-5H-1-苯并吖庚因衍生物或其药学上可接受的盐 。
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2.发明授权4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof 有权4,4-二氟-1,2,3,4-四氢-5h-1-苯并氮杂衍生物或其盐公开(公告)号：US07183271B2
公开(公告)日：2007-02-27
申请号：US10554150
申请日：2004-04-26
IPC分类号： A61P7/12 , A61K31/55 , C07D223/16
CPC分类号： C07D401/06 , C07D223/16
摘要： A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided.
摘要翻译： 提供了可用作治疗或预防夜尿和/或尿崩症的药剂的新型的4,4-二氟-1,2,3,4-四氢-5H-1-苯并吖庚因衍生物或其药学上可接受的盐 。
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3.发明申请4,4-Difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or salt thereof 有权4,4-二氟-1,2,3,4-四氢-5H-1-苯并氮杂衍生物或其盐公开(公告)号：US20070167429A1
公开(公告)日：2007-07-19
申请号：US11598732
申请日：2006-11-14
IPC分类号： A01N43/00
CPC分类号： C07D401/06 , C07D223/16
摘要： A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided.
摘要翻译： 提供了可用作治疗或预防夜尿和/或尿崩症的药剂的新型的4,4-二氟-1,2,3,4-四氢-5H-1-苯并吖庚因衍生物或其药学上可接受的盐 。
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4.发明申请4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof 有权4,4-二氟-1,2,3,4-四氢-5h-1-苯并氮杂衍生物或其盐公开(公告)号：US20060122170A1
公开(公告)日：2006-06-08
申请号：US10554150
申请日：2004-04-26
IPC分类号： A61K31/55 , C07D403/02
CPC分类号： C07D401/06 , C07D223/16
摘要： A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided.
摘要翻译： 提供了可用作治疗或预防夜尿和/或尿崩症的药剂的新型的4,4-二氟-1,2,3,4-四氢-5H-1-苯并吖庚因衍生物或其药学上可接受的盐 。
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5.发明授权公开(公告)号：US07919494B2
公开(公告)日：2011-04-05
申请号：US12543690
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译： 新型吡啶基非芳族含氮杂环-1-羧酸酯化合物及其药学上可接受的盐具有有效的FAAH抑制活性。 此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。
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6.发明申请Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound 有权含吡啶基非芳香族氮的杂环-1-羧酸酯化合物公开(公告)号：US20100009971A1
公开(公告)日：2010-01-14
申请号：US12543659
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/4709 , A61K31/444 , C07D413/12 , C07D401/12 , A61P25/00 , C07D405/14 , A61P13/00
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译： 新型吡啶基非芳族含氮杂环-1-羧酸盐化合物或其药学上可接受的盐具有有效的FAAH抑制活性。 此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。
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7.发明申请Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Compound 有权含吡啶基非芳香族氮的杂环-1-羧酸酯化合物公开(公告)号：US20100009972A1
公开(公告)日：2010-01-14
申请号：US12543690
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , C07D401/12 , C07D405/14 , A61K31/506 , A61K31/551 , A61K31/4725 , A61P13/00
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译： 新型吡啶基非芳族含氮杂环-1-羧酸酯化合物及其药学上可接受的盐具有有效的FAAH抑制活性。 此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。
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8.发明授权公开(公告)号：US07919495B2
公开(公告)日：2011-04-05
申请号：US11816508
申请日：2006-02-16
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/496 , A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： To provide a compound usable for treatment of diseases associated with fatty acid amide hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译： 提供可用于治疗与脂肪酸酰胺水解酶（FAAH）相关的疾病的化合物，特别是用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。 我们已经发现，新的吡啶基非芳族含氮杂环-1-羧酸酯衍生物及其药学上可接受的盐具有有效的FAAH抑制活性。 此外，本发明的吡啶基非芳香族含氮杂环-1-羧酸酯衍生物对提高膀胱容量有效，尿失禁效果优异，抗异常性疼痛效果优异，因此可以使用 用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。
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9.发明授权公开(公告)号：US07915261B2
公开(公告)日：2011-03-29
申请号：US12543659
申请日：2009-08-19
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , C07D401/12
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： A novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound or its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound of the present disclosure is also useful in the treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译： 新型吡啶基非芳族含氮杂环-1-羧酸盐化合物或其药学上可接受的盐具有有效的FAAH抑制活性。 此外，本公开的吡啶基非芳族含氮杂环-1-羧酸酯化合物也可用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。
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10.发明申请Pyridyl Non-Aromatic Nitrogen-Containing Heterocyclic-1-Carboxylate Derivative 有权含吡啶基非芳香族氮的杂环-1-羧酸酯衍生物公开(公告)号：US20080306046A1
公开(公告)日：2008-12-11
申请号：US11816508
申请日：2006-02-16
申请人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
发明人： Takahiro Ishii , Takashi Sugane , Jun Maeda , Fumie Narazaki , Akio Kakefuda , Kentaro Sato , Tatsuhisa Takahashi , Takatoshi Kanayama , Chikashi Saitoh , Jotaro Suzuki , Chisato Kanai
IPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , A61K31/472 , A61K31/55 , A61P13/00 , A61P25/00 , A61K31/551 , A61K31/496 , C07D401/04 , C07D243/08
CPC分类号： A61K31/44 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D401/12
摘要： [Problem] To provide a compound usable for treatment of diseases associated with fatty acid amide hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.[Means for Solution] We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.
摘要翻译： 提供可用于治疗与脂肪酰胺水解酶（FAAH）相关的疾病的化合物，特别是用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛的化合物。 [解决方案]我们已经发现，新的吡啶基非芳族含氮杂环-1-羧酸酯衍生物及其药学上可接受的盐具有有效的FAAH抑制活性。 此外，本发明的吡啶基非芳香族含氮杂环-1-羧酸酯衍生物对提高膀胱容量有效，尿失禁效果优异，抗异常性疼痛效果优异，因此可以使用 用于治疗尿频和尿失禁，膀胱过度活动和/或疼痛。
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