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    Cephalosporin compounds
    1.
    发明授权
    Cephalosporin compounds 失效
    头孢菌素化合物

    公开(公告)号：US5389625A

    公开(公告)日：1995-02-14

    申请号：US849019

    申请日：1992-06-08

    申请人： Hiroyuki Muro ,  Masayasu Kasai ,  Satoru Hatano ,  Ken-ichi Nishimura ,  Susumu Nishizawa ,  Nobuharu Kakeya

    发明人： Hiroyuki Muro ,  Masayasu Kasai ,  Satoru Hatano ,  Ken-ichi Nishimura ,  Susumu Nishizawa ,  Nobuharu Kakeya

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22

    CPC分类号： C07D501/00 ,  Y02P20/55

    摘要： Cephalosporin compounds of the formula (I) ##STR1## wherein R.sup.1 is hydrogen atom or lower alkyl, and R.sup.2 is 1-alkanoyloxyalkyl or 1-alkoxycarbonyloxyalkyl, their pharmaceutically acceptable salts, methods for producing them, and pharmaceutical use thereof.The cephalosporin compounds and their salts are superior in absorption from digestive tract, and upon absorption from the digestive tract, show a wide range of antimicrobial activities in the body as hydrolysis products, and in addition, they have 10-400 times greater sweetness than sucrose. Thus, said compounds are useful as agents to be administered orally for the prophylaxis and treatment of bacterial infectious diseases.

    摘要翻译： PCT No.PCT / JP90 / 01370 Sec。 371日期：1992年6月8日 102（e）日期1992年6月8日PCT 1990年10月24日PCT PCT。 出版物WO91 / 06549 日本1991年5月16日。式（I）r烷基和R 2的头孢菌素化合物是1-烷酰氧基烷基或1-烷氧基羰氧基烷基，其药学上可接受的盐，其制备方法及其药物用途。 头孢菌素化合物及其盐在消化道吸收方面优越，并且在消化道吸收时，作为水解产物在体内表现出广泛的抗微生物活性，此外，它们的甜度比蔗糖高10-400倍 。 因此，所述化合物可用作口服给药以预防和治疗细菌感染性疾病的药剂。

    Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use
    3.
    发明授权
    Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use 失效
    吸收促进化合物，其组合物与用于直肠给药的药物和/或碱基和使用方法

    公开(公告)号：US4442090A

    公开(公告)日：1984-04-10

    申请号：US246953

    申请日：1981-03-24

    申请人： Nobuharu Kakeya ,  Kazuhiko Kitao ,  Ken-ichi Nishimura

    发明人： Nobuharu Kakeya ,  Kazuhiko Kitao ,  Ken-ichi Nishimura

    IPC分类号： A61K9/02 ,  A61K47/18 ,  A61K37/26 ,  A61K31/425 ,  A61K31/54 ,  A61K37/00

    CPC分类号： A61K9/02 ,  A61K47/183 ,  Y10S424/15

    摘要： Compounds satisfying four specific requirements, namely: (1) a log P value in the range of from 2.5 to 6, (2) a molecular structure with at least one carboxyl group, (3) a pKa value for the carboxyl group of not less than 2.5 and (4) absence of halo substitution, and nontoxic salts thereof promote absorption of pharmacologically-active substance through the rectum into the bloodstream and are effective to raise the concentration of such active substance in the bloodstream even when the active substance is usually unabsorbable or absorbable through the rectum only with considerable difficulty. The compounds are combined with pharmacologically-active ingredients, with pharmaceutical bases suitable for rectal administration of drugs and with appropriate combinations of both.

    摘要翻译： 满足四个具体要求的化合物，即：（1）log值在2.5至6的范围内，（2）具有至少一个羧基的分子结构，（3）羧基的pKa值不低于 超过2.5和（4）不存在卤素取代，并且其无毒盐促进药物活性物质通过直肠吸收到血液中，并且有效地提高这种活性物质在血流中的浓度，即使活性物质通常是不可吸收的 或通过直肠吸收只有相当大的困难。 将化合物与药理学活性成分组合，其中适合于直肠给药的药物基质和两者的适当组合。

    Automatic facsimile signal analyzing apparatus for a telephone exchange system
    5.
    发明授权
    Automatic facsimile signal analyzing apparatus for a telephone exchange system 失效
    用于电话交换系统的自动传真信号分析装置

    公开(公告)号：US5726767A

    公开(公告)日：1998-03-10

    申请号：US497077

    申请日：1995-06-30

    申请人： Hiroshi Kumakura ,  Takashi Itani ,  Ken-ichi Nishimura ,  Hideki Amano ,  Masayoshi Sato

    发明人： Hiroshi Kumakura ,  Takashi Itani ,  Ken-ichi Nishimura ,  Hideki Amano ,  Masayoshi Sato

    IPC分类号： H04M11/00 ,  H04M11/06 ,  H04N1/00 ,  H04N1/32 ,  H04M1/00 ,  H04N11/00

    CPC分类号： H04N1/0001 ,  H04M11/06 ,  H04N1/00002 ,  H04N1/00042 ,  H04N1/0005 ,  H04N1/00058

    摘要： An automatic facsimile signal analyzing system includes a switch unit, a service trunk, a signal identification trunk, a facsimile communication determination unit, and a control unit. The signal identification trunk restores a facsimile control signal from a modulated and encoded facsimile signal on the set speech path and performs collection of communication state information and detection of a start of facsimile communication on the basis of the restored facsimile control signal. The facsimile communication determination unit permits an operation of the signal identification trunk when the classification result from the service trunk represents a type other than the voice signal and analyzes the communication state information from the signal identification trunk. The control unit performs switching/connection control of the switch unit, connects the service trunk and the signal identification trunk, both of which are in an idle state, to the set speech path upon setting of the speech path, disconnects the service trunk from the speech path when the classification result is output, and disconnects the signal identification trunk from the set speech path when the classification result from the service trunk represents the voice signal and when a call corresponding to the set speech path is ended.

    摘要翻译： 自动传真信号分析系统包括开关单元，服务中继线，信号识别中继线，传真通信确定单元和控制单元。 信号识别中继从设定语音路径上的调制和编码的传真信号中恢复传真控制信号，并根据恢复的传真控制信号执行通信状态信息的收集和传真通信的开始检测。 当来自业务中继的分类结果表示除语音信号之外的类型时，传真通信确定单元允许信号识别中继线的操作，并分析来自信号识别中继线的通信状态信息。 控制单元执行开关单元的切换/连接控制，在设置语音路径时将服务中继线和信号识别中继线两者都处于空闲状态，并将其连接到设定语音路径 输出分类结果时的语音路径，当来自业务中继的分类结果表示语音信号时，以及当对应于所设定的语音路径的呼叫结束时，断开信号识别中继与设定语音路径的连接。