公开(公告)号：US11850311B2

公开(公告)日：2023-12-26

申请号：US17281621

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/407

CPC classification number: A61K9/7069 ,  A61K31/407

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

公开(公告)号：US11033511B2

公开(公告)日：2021-06-15

申请号：US16610955

申请日：2018-07-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Akira Shuto ,  Takao Kurokawa ,  Junya Horiuchi ,  Hidekazu Kuma ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/216

Abstract: The present invention provides a patch comprising a backing, and an adhesive layer on the backing, wherein the adhesive layer contains at least one drug selected from the group consisting of oxybutynin and a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive base, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0007 to 0.05% by mass based on the total mass of the adhesive layer.

公开(公告)号：US10806705B2

公开(公告)日：2020-10-20

申请号：US15745266

申请日：2016-07-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takashi Yasukochi ,  Atsushi Sonobe ,  Satoshi Amano

IPC: A61K47/18 ,  A61K9/70 ,  A61K31/407 ,  A61K47/14

Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.

公开(公告)号：US20210369637A1

公开(公告)日：2021-12-02

申请号：US17281621

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/407

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.