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    1-adamantyl azetidin-2-one derivatives and drugs containing same
    4.
    发明授权
    1-adamantyl azetidin-2-one derivatives and drugs containing same 有权
    1-金刚烷基氮杂环丁烷-2-酮衍生物和含有它们的药物

    公开(公告)号：US08236789B2

    公开(公告)日：2012-08-07

    申请号：US12550206

    申请日：2009-08-28

    申请人： Hisashi Nakashima ,  Takahiro Mori ,  Ryoko Mori, legal representative ,  Takaaki Araki ,  Takahisa Ogamino ,  Kazutoyo Abe ,  Tadaaki Ohgiya

    发明人： Hisashi Nakashima ,  Takahiro Mori ,  Takaaki Araki ,  Takahisa Ogamino ,  Kazutoyo Abe ,  Tadaaki Ohgiya

    IPC分类号： C07D205/08 ,  C07D227/087 ,  A61K31/397 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4725 ,  A61P3/10 ,  A61P3/04 ,  A61P9/12 ,  A61P3/06

    CPC分类号： C07D205/08 ,  A61K31/397 ,  C07D401/04 ,  C07D401/08 ,  C07D405/04

    摘要： It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate. [wherein A ring represents C6-10 aryl group, 5- to 14-membered heteroaryl group, R1 is a hydrogen atom, halogen atom, C1-6 alkoxycarbonyl group, hydroxyl group, carboxyl group or carbamoyl group; R2 and R3 are the same or different and are a C1-6 alkyl group; R4, R5, and R6 are same or different, and are a hydrogen atom, halogen atom, C1-6 alkyl group, C1-6 alkoxy group, C6-10 aryl group, or R4 and R5, or R5 and R6 may together form a C1-3 alkylenedioxy group, R7 and R8 are the same of different and represent a hydrogen atom or C1-6 alkyl group, or may together form a C3-6 cyclic hydrocarbon group, n represents an integer of 0 or 1].

    摘要翻译： 提供一种可用于预防和/或治疗涉及11-羟基类固醇脱氢酶1，特别是糖尿病，胰岛素抵抗，糖尿病并发症，肥胖，血脂异常，高血压，脂肪肝或代谢综合征的疾病的新型化合物。 它是由以下通式（1）表示的1-金刚烷基氮杂环丁-2-酮衍生物或其盐或其溶剂合物。 [其中A环表示C6-10芳基，5〜14元杂芳基，R1表示氢原子，卤素原子，C1-6烷氧基羰基，羟基，羧基或氨基甲酰基。 R2和R3相同或不同，为C1-6烷基; R 4，R 5和R 6相同或不同，为氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基，C 6-10芳基或R 4和R 5，或者R 5和R 6可以一起形成 C 1-3亚烷基二氧基，R 7和R 8相同，表示氢原子或C 1-6烷基，或一起形成C 3-6环烃基，n表示0或1的整数]。

    1-ADAMANTYLAZETIDIN-2-ONE DERIVATIVES AND DRUGS CONTAINING SAME
    5.
    发明申请
    1-ADAMANTYLAZETIDIN-2-ONE DERIVATIVES AND DRUGS CONTAINING SAME 有权
    1-ADAMANTYLAZETIDIN-2-ONE衍生物和含有其的药物

    公开(公告)号：US20100075943A1

    公开(公告)日：2010-03-25

    申请号：US12550206

    申请日：2009-08-28

    申请人： Hisashi Nakashima ,  Takahiro Mori ,  Takaaki Araki ,  Takahisa Ogamino ,  Kazutoyo Abe ,  Tadaaki Ohgiya ,  Ryoko Mori

    发明人： Hisashi Nakashima ,  Takahiro Mori ,  Takaaki Araki ,  Takahisa Ogamino ,  Kazutoyo Abe ,  Tadaaki Ohgiya ,  Ryoko Mori

    IPC分类号： A61K31/397 ,  C07D205/04 ,  A61P3/00

    CPC分类号： C07D205/08 ,  A61K31/397 ,  C07D401/04 ,  C07D401/08 ,  C07D405/04

    摘要： It is to provide a novel compound useful for preventing and/or treating diseases that involves 11β-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate. [wherein A ring represents C6-10 aryl group, 5- to 14-membered heteroaryl group, R1 is a hydrogen atom, halogen atom, C1-6 alkoxycarbonyl group, hydroxyl group, carboxyl group or carbamoyl group; R2 and R3 are the same or different and are a C1-6 alkyl group; R4, R5, and R6 are same or different, and are a hydrogen atom, halogen atom, C1-6 alkyl group, C1-6 alkoxy group, C6-10 aryl group, or R4 and R5, or R5 and R6 may together form a C1-3 alkylenedioxy group, R7 and R8 are the same of different and represent a hydrogen atom or C1-6 alkyl group, or may together form a C3-6 cyclic hydrocarbon group, n represents an integer of 0 or 1]

    摘要翻译： 提供一种可用于预防和/或治疗涉及11-羟基类固醇脱氢酶1，特别是糖尿病，胰岛素抵抗，糖尿病并发症，肥胖，血脂异常，高血压，脂肪肝或代谢综合征的疾病的新化合物。 它是由以下通式（1）表示的1-金刚烷基氮杂环丁-2-酮衍生物或其盐或其溶剂合物。 [其中A环表示C6-10芳基，5〜14元杂芳基，R1表示氢原子，卤素原子，C1-6烷氧基羰基，羟基，羧基或氨基甲酰基。 R2和R3相同或不同，为C1-6烷基; R 4，R 5和R 6相同或不同，为氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基，C 6-10芳基或R 4和R 5，或者R 5和R 6可以一起形成 C 1-3亚烷基二氧基，R 7和R 8相同，表示氢原子或C 1-6烷基，或一起形成C 3-6环烃基，n表示0或1的整数]