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公开(公告)号：US20070059277A1
公开(公告)日：2007-03-15
申请号：US11519982
申请日：2006-09-12
申请人： Hitesh Bhagat , Jeffrey Goldberg
发明人： Hitesh Bhagat , Jeffrey Goldberg
IPC分类号： A61K31/785
CPC分类号： A61K31/787 , A61K8/8105 , A61K8/817 , A61K8/898 , A61K9/0053 , A61K9/0056 , A61K9/0095 , A61K9/1652 , A61K31/00 , A61K31/785 , A61K47/34 , A61K47/36
摘要： A powder formulation comprises a pharmaceutically acceptable anionic stabilizer and an aliphatic amine polymer or a pharmaceutically acceptable salt thereof mixed with the anionic stabilizer. The powder formulation is conveniently packaged in a container, such as a sachet. A method of treating a subject with hyperphosphotemia with the powder formulation is also disclosed.
摘要翻译： 粉末制剂包含与阴离子稳定剂混合的药学上可接受的阴离子稳定剂和脂族胺聚合物或其药学上可接受的盐。 粉末制剂方便地包装在容器中，例如小袋。 还公开了用粉末制剂治疗患有高光合速率的受试者的方法。
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公开(公告)号：US20060251614A1
公开(公告)日：2006-11-09
申请号：US11262291
申请日：2005-10-27
IPC分类号： A61K31/785 , A61K9/20
CPC分类号： A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/13 , A61K31/785 , A61K47/02 , A61K47/34
摘要： The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.
摘要翻译： 包含脂族胺聚合物和单价阴离子的碳酸盐的本发明的片剂，组合物和方法可以预防或改善酸中毒，特别是肾病患者的酸中毒。 本发明的片剂和组合物在60℃下在37℃和至少1℃的pH下保持不超过30分钟至少10周的崩解时间。此外，片剂对于 延长的时间段，而不需要专门的储存条件。
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3.发明申请Poly(potassium and sodium styrene sulfonate), its manufacture and its uses 审中-公开聚（苯乙烯磺酸钠和苯磺酸钠），其制造及其用途公开(公告)号：US20050214246A1
公开(公告)日：2005-09-29
申请号：US11039351
申请日：2005-01-20
申请人： Sunil Mhaskar , Hitesh Bhagat , Caroline Bacon Kurtz , Sanjeev Katti , Toni Chancellor-Adams , Mukund Chorghade
发明人： Sunil Mhaskar , Hitesh Bhagat , Caroline Bacon Kurtz , Sanjeev Katti , Toni Chancellor-Adams , Mukund Chorghade
IPC分类号： A61K31/74 , A61K31/795 , C08F8/34 , C08F8/36 , C08L25/18
CPC分类号： A61K31/795 , A61K31/74 , C08F8/44 , C08L25/18 , A61K2300/00 , C08F112/14
摘要： Antibiotic-associated diarrhea, such as that caused by Clostridium difficile, represents a serious medical complication that can result from administering a broad-spectrum antibiotic to a subject. Such diarrhea leads to significant potassium loss from the subject. The present invention discloses a polymeric therapeutic agent that treats antibiotic-associated diarrhea and is physiologically potassium neutral. This polymer contains polystyrene sodium sulfonate and polystyrene potassium sulfonate repeat units.
摘要翻译： 抗生素相关性腹泻，例如艰难梭菌引起的腹泻，代表了对受试者施用广谱抗生素可能导致的严重的医学并发症。 这种腹泻导致受试者显着的钾损失。 本发明公开了治疗抗生素相关性腹泻并且是生理钾中性的聚合治疗剂。 该聚合物含有聚苯乙烯磺酸钠和聚苯乙烯磺酸钾重复单元。
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公开(公告)号：US20100316589A1
公开(公告)日：2010-12-16
申请号：US12808039
申请日：2008-12-12
申请人： Hitesh Bhagat , Adnan Salameh
发明人： Hitesh Bhagat , Adnan Salameh
IPC分类号： A61K31/785 , A61P3/00 , A61P13/12
摘要： The present invention relates to polycarbophil coated crosslinked amine polymers and/or pharmaceutical compositions comprising polycarbophil coated crosslinked amine polymers. The polycarbophil coated crosslinked amine polymers have several therapeutic applications, including, but not limited to, hyperphosphatemia, chronic kidney disease and End-Stage Renal Disease.
摘要翻译： 本发明涉及包含聚卡布非尔涂覆的交联胺聚合物的聚卡波非涂层交联胺聚合物和/或药物组合物。 聚卡波非涂覆的交联胺聚合物具有几种治疗应用，包括但不限于高磷酸盐血症，慢性肾脏疾病和终末期肾脏疾病。
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公开(公告)号：US5837240A
公开(公告)日：1998-11-17
申请号：US920095
申请日：1997-08-26
申请人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
发明人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
IPC分类号： A61K38/46 , A61K39/02 , A61K39/106
CPC分类号： A61K39/105 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
摘要翻译： 提供了用于幽门螺杆菌的预防和抗菌治疗的方法和组合物，特别是用于幽门螺杆菌，人的感染。 本发明的免疫原性组合物由多个多聚体复合物组成，每个复合物由重组的酶促活化的幽门螺旋杆菌脲酶组成。 每个多聚体复合物由六个脲酶A亚基和六个脲酶B亚基组成。 或者，组合物由多聚体复合物的混合物组成，其中混合物中的每个多聚复合物由六个脲酶A亚基和六个脲酶B亚基或四个脲酶A亚基和四个脲酶B亚基组成。
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公开(公告)号：US20070098678A1
公开(公告)日：2007-05-03
申请号：US11475385
申请日：2006-06-26
IPC分类号： A61K31/785 , A61K9/20
CPC分类号： A61K9/2866 , A61K9/2846 , A61K9/5026 , A61K31/785
摘要： Tablets, capsules, sachets, or papers having one or more aliphatic amine polymers allow for the targeted release of the polymers at a specific region of the gastrointestinal tract, especially the small intestine. These tablets, capsules, sachets, or papers are useful in a method for lowering cholesterol in a mammal in need thereof. The tablet includes a tablet core having an aliphatic amine polymer, and an enteric coating for the core. The capsule, sachet or paper includes a plurality of beads where the beads have a bead core having an aliphatic amine polymer, an enteric coating therefor and optionally a water-soluble coating.
摘要翻译： 具有一种或多种脂族胺聚合物的片剂，胶囊，小药囊或纸可以在胃肠道特别是小肠的特定区域靶向释放聚合物。 这些片剂，胶囊，小药囊或纸可用于有需要的哺乳动物中降低胆固醇的方法。 片剂包括具有脂族胺聚合物的片芯和用于核心的肠溶衣。 胶囊，小药囊或纸包括多个珠，其中珠具有具有脂族胺聚合物的珠芯，其肠溶衣和任选的水溶性涂层。
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