公开(公告)号：US20080311228A1

公开(公告)日：2008-12-18

申请号：US11762350

申请日：2007-06-13

申请人： Ho Cheol Kim ,  Ha Young Lee ,  Ni Na Ha ,  Min Jung Kong ,  Seung Ju Rho ,  Nak Sul Seong ,  Geum Soog Kim ,  Yun Tai Kim ,  Youngmin Bu

发明人： Ho Cheol Kim ,  Ha Young Lee ,  Ni Na Ha ,  Min Jung Kong ,  Seung Ju Rho ,  Nak Sul Seong ,  Geum Soog Kim ,  Yun Tai Kim ,  Youngmin Bu

IPC分类号： A61K36/30 ,  A61K31/22 ,  A61P25/00

CPC分类号： A61K36/30 ,  A61K31/22

摘要： The present invention relates to a pharmaceutical composition for protecting neurons or for preventing and treating ischemic neuronal diseases comprising the extract of Lithospermum erythrorhizon Sieb. Et Zucc extracted with water, low-alcohols or their mixture or acetylshikonin separated therefrom as an effective ingredient. The extract of Lithospermum erythrorhizon Sieb. Et. Zucc or acetylshikonin separated therefrom of the present invention has neuronal protective effect, so that it not only interrupts the development of ischemic neuronal diseases but also is very safe, indicating that the extract or acetylshikonin can be used as a medicinal drug for prevention and treatment of degenerative brain disease caused by neuronal apoptosis such as stroke, apoplexy, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, Pick's disease and Creutzfeldt-Jakob disease and further can be developed as functional health food.

摘要翻译： 本发明涉及一种用于保护神经元或预防和治疗缺血性神经元疾病的药物组合物，其包含紫苏红提取物的提取物。 Et Zucc用水，低级醇或其混合物或与其分离的乙酰紫草素作为有效成分提取。 紫草提取物。 等等 本发明分离的Zucc或乙酰基紫草素具有神经元保护作用，不仅中断缺血性神经元疾病的发展，而且非常安全，表明提取物或乙酰草酮可用作预防和治疗的药物 由脑卒中，中风，痴呆，阿尔茨海默病，帕金森氏病，亨廷顿舞蹈病，皮克病和克ut特 - 雅各布病引起的退行性脑病也可作为功能保健食品开发。

公开(公告)号：US07731994B2

公开(公告)日：2010-06-08

申请号：US11762350

申请日：2007-06-13

申请人： Ho Cheol Kim ,  Ha Young Lee ,  Ni Na Ha ,  Min Jung Kong ,  Seung Ju Roh ,  Nak Sul Seong ,  Geum Soog Kim ,  Yun Tai Kim ,  Youngmin Bu

发明人： Ho Cheol Kim ,  Ha Young Lee ,  Ni Na Ha ,  Min Jung Kong ,  Seung Ju Roh ,  Nak Sul Seong ,  Geum Soog Kim ,  Yun Tai Kim ,  Youngmin Bu

IPC分类号： A61K36/00

CPC分类号： A61K36/30 ,  A61K31/22

摘要： The present invention relates to a pharmaceutical composition for protecting neurons or for preventing and treating ischemic neuronal diseases comprising the extract of Lithospermum erythrorhizon Sieb. Et Zucc extracted with water, low-alcohols or their mixture or acetylshikonin separated therefrom as an effective ingredient. The extract of Lithospermum erythrorhizon Sieb. Et. Zucc or acetylshikonin separated therefrom of the present invention has neuronal protective effect, so that it not only interrupts the development of ischemic neuronal diseases but also is very safe, indicating that the extract or acetylshikonin can be used as a medicinal drug for prevention and treatment of degenerative brain disease caused by neuronal apoptosis such as stroke, apoplexy, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, Pick's disease and Creutzfeldt-Jakob disease and further can be developed as functional health food.

摘要翻译： 本发明涉及一种用于保护神经元或预防和治疗缺血性神经元疾病的药物组合物，其包含紫苏红提取物的提取物。 Et Zucc用水，低级醇或其混合物或与其分离的乙酰紫草素作为有效成分提取。 紫草提取物。 等等 本发明分离的Zucc或乙酰基紫草素具有神经元保护作用，不仅中断缺血性神经元疾病的发展，而且非常安全，表明提取物或乙酰草酮可用作预防和治疗的药物 由脑卒中，中风，痴呆，阿尔茨海默病，帕金森氏病，亨廷顿舞蹈病，皮克病和克ut特 - 雅各布病引起的退行性脑病也可作为功能保健食品开发。