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公开(公告)号：US20230050901A1
公开(公告)日：2023-02-16
申请号：US17749496
申请日：2022-05-20
发明人： Charles BELL , Joerg BENZ , Luca GOBBI , Uwe GRETHER , Katrin GROEBKE ZBINDEN , Benoit HORNSPERGER , Buelent KOCER , Carsten KROLL , Bernd KUHN , Marius Daniel Rinaldo LUTZ , Fionn O'HARA , Hans RICHTER , Martin RITTER , Didier ROMBACH , Martin KURATLI
IPC分类号： C07D498/04 , C07D519/00
摘要： The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20200308190A1
公开(公告)日：2020-10-01
申请号：US16844262
申请日：2020-04-09
发明人： Charles BELL , Joerg BENZ , Luca GOBBI , Uwe GRETHER , Katrin GROEBKE ZBINDEN , Benoit HORNSPERGER , Buelent KOCER , Carsten KROLL , Bernd KUHN , Marius Daniel Rinaldo LUTZ , Fionn O'HARA , Hans RICHTER , Martin RITTER , Didier ROMBACH , Martin KURATLI
IPC分类号： C07D498/04 , C07D519/00
摘要： The invention provides new heterocyclic compounds having the general formula wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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![OCTAHYDROPYRIDO[1,2-ALPHA]PYRAZINES AS MAGL INHIBITORS](/abs-image/US/2021/01/28/US20210024546A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210024546A1
公开(公告)日：2021-01-28
申请号：US16922427
申请日：2020-07-07
发明人： Ann PETERSEN , Joerg BENZ , Uwe GRETHER , Benoit HORNSPERGER , Buelent KOCER , Bernd KUHN , Hans RICHTER , Satoshi TSUCHIYA , Yangcheng QIU , Rui CHEN
IPC分类号： C07D519/00 , C07D471/04
摘要： The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20200299277A1
公开(公告)日：2020-09-24
申请号：US16827211
申请日：2020-03-23
发明人： Joerg BENZ , Uwe GRETHER , Benoit HORNSPERGER , Bernd KUHN , Hans RICHTER , Buelent KOCER , Fionn O'HARA , Martin RITTER , Satoshi TSUCHIYA , Ludovic COLLIN , Simon E. JOHNSON , Charles BELL
IPC分类号： C07D403/14 , C07D403/04 , C07D413/14 , C07D401/14 , C07D417/14 , C07D405/14 , C07D471/04 , C07D471/08 , C07D491/107 , C07D487/10
摘要： The invention provides new heterocyclic compounds having the general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20230117324A1
公开(公告)日：2023-04-20
申请号：US17818459
申请日：2022-08-09
发明人： Charles BELL , Joerg BENZ , Luca GOBBI , Uwe GRETHER , Katrin GROEBKE ZBINDEN , Dennis Jul HANSEN , Benoit HORNSPERGER , Buelent KOCER , Carsten KROLL , Bernd KUHN , Fionn O'HARA , Hans RICHTER , Martin RITTER , Satoshi TSUCHIYA , Rui CHEN
IPC分类号： C07D498/04 , A61K9/20 , A61K9/48 , C07D519/00
摘要： The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20210107920A1
公开(公告)日：2021-04-15
申请号：US17025155
申请日：2020-09-18
发明人： Charles BELL , Joerg BENZ , Luca GOBBI , Uwe GRETHER , Katrin GROEBKE ZBINDEN , Dennis Jul HANSEN , Benoit HORNSPERGER , Buelent KOCER , Carsten KROLL , Bernd KUHN , Fionn O'HARA , Hans RICHTER , Martin RITTER , Satoshi TSUCHIYA , Rui CHEN
IPC分类号： C07D498/04 , C07D519/00 , A61K9/20 , A61K9/48
摘要： The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20200308158A1
公开(公告)日：2020-10-01
申请号：US16899928
申请日：2020-06-12
发明人： Charles BELL , Joerg BENZ , Uwe GRETHER , Benoit HORNSPERGER , Buelent KOCER , Bernd KUHN , Hans RICHTER , Satoshi TSUCHIYA
IPC分类号： C07D413/06 , C07D413/14 , C07D498/04
摘要： The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
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公开(公告)号：US20180148450A1
公开(公告)日：2018-05-31
申请号：US15850826
申请日：2017-12-21
发明人： Bernd BUETTELMANN , Buelent KOCER , Bernd KUHN , Marco PRUNOTTO , Hans RICHTER , Martin RITTER , Markus RUDOLPH , Alexander Lee SATZ
IPC分类号： C07D471/10 , C07D519/00 , A61P13/12 , A61P1/16 , A61P9/00 , A61P35/00 , A61P37/06
CPC分类号： C07D471/10 , A61P1/16 , A61P9/00 , A61P13/12 , A61P35/00 , A61P37/06 , C07D519/00
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein L and R1 to R5 are as described herein, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.
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