公开(公告)号：US20240035032A1

公开(公告)日：2024-02-01

申请号：US18114626

申请日：2023-02-27

Applicant: Hoffmann-La Roche Inc.

Inventor： Hassan JAVANBAKH ,  Søren OTTOSEN ,  Morten LINDOW

IPC: C12N15/113 ,  A61K47/54 ,  A61K31/713

CPC classification number: C12N15/1131 ,  A61K47/549 ,  A61K47/554 ,  C12N15/1133 ,  A61K31/713 ,  C12N2310/351 ,  C12N2320/30 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/346 ,  C12N2310/3515

Abstract: The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.

公开(公告)号：US20210054381A1

公开(公告)日：2021-02-25

申请号：US17013374

申请日：2020-09-04

Applicant: Hoffmann-La Roche Inc.

Inventor： Hassan JAVANBAKH ,  Søren OTTOSEN ,  Morten LINDOW

IPC: C12N15/113 ,  A61K47/54 ,  A61K31/713

Abstract: The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.

公开(公告)号：US20160010093A1

公开(公告)日：2016-01-14

申请号：US14714004

申请日：2015-05-15

Applicant: HOFFMANN-LA ROCHE INC.

Inventor： Hassan JAVANBAKH ,  Søren OTTOSEN ,  Morten LINDOW

IPC: C12N15/113 ,  A61K47/48 ,  A61K31/713

Abstract: The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.

Abstract translation: 本发明涉及用于治疗病毒性疾病的低聚物缀合物。 所述寡聚物缀合物包含：a）能够调节乙型肝炎病毒（HBV）的HBx和/或HBsAg中的靶序列以治疗所述病毒性病症的寡聚物; 和b）能够将低聚物递送至与低聚物连接，优选缀合的肝的载体组分。