公开(公告)号：US20230120311A1

公开(公告)日：2023-04-20

申请号：US17946743

申请日：2022-09-16

申请人： Hoffmann-La Roche Inc.

发明人： Kirsten Andrea Graeser ,  Urs Schwitter ,  Frank Stowasser ,  Florence Nicole Antoinette Tixeront ,  Rene Trussardi

IPC分类号： C07D413/12

摘要： Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the TAAR1 agonist 5-ethyl-4-methyl-N-[4-[(2S) morpholin-2-yl]phenyl]-1H-pyrazole-3-carboxamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the TAAR1 agonist, and methods of using the TAAR1 agonist, alone and in combination with other compounds, for treating diseases or conditions that are associated with TAAR1 activity.