-
公开(公告)号：US20230052521A1
公开(公告)日：2023-02-16
申请号：US17748707
申请日：2022-05-19
发明人： Marina BACAC , Stefan EVERS , Christian KLEIN , Pavel PISA , Eva ROSSMANN , Jose SARO , Pablo UMANA
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28
摘要： The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
-
公开(公告)号：US20210252144A1
公开(公告)日：2021-08-19
申请号：US17240821
申请日：2021-04-26
发明人： Marina BACAC , Stefan EVERS , Christian KLEIN , Pavel PISA , Eva ROSSMANN , Jose SARO , Pablo UMANA
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28
摘要： The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
-
公开(公告)号：US20210101996A1
公开(公告)日：2021-04-08
申请号：US17117598
申请日：2020-12-10
发明人： Christian KLEIN , Marina BACAC , Anne FREIMOSER-GRUNDSCHOBER , Sylvia HERTER , Joaquin ARRIBAS , Rocio VICARIO
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
-
4.发明申请公开(公告)号：US20200325238A1
公开(公告)日：2020-10-15
申请号：US16820504
申请日：2020-03-16
发明人： Marina BACAC , Claudia FERRARA KOLLER , Christian KLEIN , Mario PERRO , Johannes SAM , Pablo UMAÑA , Wei XU
IPC分类号： C07K16/28 , A61P35/00 , C07K14/705 , C07K16/46
摘要： The present invention relates to combination therapies employing anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies.
-
公开(公告)号：US20220403027A1
公开(公告)日：2022-12-22
申请号：US17711489
申请日：2022-04-01
发明人： Oliver AST , Marina BACAC , Sabine IMHOF-JUNG , Christiane NEUMANN , Christian KLEIN , Stefan KLOSTERMANN , Michael MOLHOJ , Joerg Thomas REGULA , Wolfgang SCHAEFER , Pablo UMANA
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
-
公开(公告)号：US20210355234A1
公开(公告)日：2021-11-18
申请号：US17443893
申请日：2021-07-28
发明人： Christian KLEIN , Marina BACAC , Anne FREIMOSER-GRUNDSCHOBER , Sylvia HERTER , Joaquin ARRIBAS , Rocio VICARIO
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
-
7.发明申请公开(公告)号：US20200376119A1
公开(公告)日：2020-12-03
申请号：US16787931
申请日：2020-02-11
发明人： Marina BACAC , Sara COLOMBETTI , Christian KLEIN , Johannes SAM , Jose SARO , Pablo UMANA
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30
摘要： The invention provides compositions and methods for treating CEA-positive cancers. The method comprising administering a PD-1 axis binding antagonist and a bispecific antibody that targets CEA and CD3.
-
公开(公告)号：US20200231673A1
公开(公告)日：2020-07-23
申请号：US16799662
申请日：2020-02-24
发明人： Oliver AST , Marina BACAC , Sabine IMHOF-JUNG , Christiane NEUMANN , Christian KLEIN , Stefan KLOSTERMANN , Michael MOLHOJ , Joerg Thomas REGULA , Wolfgang SCHAEFER , Pablo UMANA
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
-
公开(公告)号：US20180222980A1
公开(公告)日：2018-08-09
申请号：US15879040
申请日：2018-01-24
发明人： Oliver AST , Marina BACAC , Sabine IMHOF-JUNG , Christiane JAEGER , Christian KLEIN , Stefan KLOSTERMANN , Michael MOLHOJ , Joerg Thomas REGULA , Wolfgang SCHAEFER , Pablo UMANA
CPC分类号： C07K16/2809 , C07K16/2878 , C07K16/2887 , C07K16/3053 , C07K16/32 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
-
公开(公告)号：US20220054635A1
公开(公告)日：2022-02-24
申请号：US17519790
申请日：2021-11-05
发明人： Marina BACAC , Stefan EVERS , Christian KLEIN , Pavel PISA , Eva ROSSMANN , Jose SARO , Pablo UMANA
IPC分类号： A61K39/395 , C07K16/30 , C07K16/28
摘要： The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.016 秒)
