公开(公告)号：US20250017937A1

公开(公告)日：2025-01-16

申请号：US18779430

申请日：2024-07-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Theresa M. BALLARD ,  Silvia Gatti MCARTHUR ,  Michael SAXE ,  Juergen WICHMANN ,  Thomas WOLTERING

IPC: A61K31/519 ,  A61K31/444

Abstract: This invention relates to a new medical use for certain chemical compounds and pharmaceutical compositions containing them. The invention relates to compounds which are mGlu2/3 negative allosteric modulators for use in the treatment of intellectual disabilities. In another aspect, the invention relates to a pharmaceutical composition for use in the treatment of intellectual disabilities comprising a compound according to the invention and a pharmaceutically acceptable carrier.