公开(公告)号：US20250034269A1

公开(公告)日：2025-01-30

申请号：US18747055

申请日：2024-06-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Roberta Bianchi ,  Felix Bormann ,  Michelle Victoria Brydon ,  Stefan Dengl ,  Harald Duerr ,  Guy Georges ,  Lydia Jasmin Hanisch ,  Monika Heidrich ,  Ralf Hosse ,  Leo Frederik Kunz ,  Stephane Leclair ,  Desirée Leisibach ,  Fanny Mende ,  Olaf Mundigl ,  Miroslav Nikolov ,  Pablo Umaña ,  Cornelia Wagner

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/40

Abstract: The invention relates to novel antibodies that bind to lymphotoxin beta receptor (LTBR) and to bispecific antigen binding molecules comprising these novel LTBR antibodies and an antigen binding domain that binds a tumor associated antigen, in particular to Fibroblast Activation Protein (FAP), to methods of producing these molecules and to methods of using the same.