公开(公告)号：US20170197969A1

公开(公告)日：2017-07-13

申请号：US15379057

申请日：2016-12-14

申请人： Hoffmann-La Roche Inc.

发明人： Emmanuel PINARD ,  Hasane RATNI ,  Luke GREEN ,  Patrick WILLIAMSON

IPC分类号： C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The present invention provides compounds of formula (I) wherein A, X1, X2, R1, R2, R3, R4 and R5 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.