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公开(公告)号:US20100318906A1
公开(公告)日:2010-12-16
申请号:US12813173
申请日:2010-06-10
申请人: Hok-sum H. LUKE , Drew Bamford , Michael Gerhardt , David Folchi , Nathan Robertson , Martijn Van Tilburg
发明人: Hok-sum H. LUKE , Drew Bamford , Michael Gerhardt , David Folchi , Nathan Robertson , Martijn Van Tilburg
CPC分类号: G06F3/0488 , G06F3/0485
摘要: Methods for browsing image data and systems using the same are provided. First, a plurality of image data is provided. A thumbnail is created for each of the image data, wherein the respective thumbnails have the same image height. Then, a filmstrip is created according to the thumbnails, and all or a part of the filmstrip is displayed in a touch-sensitive display unit to let users browse the thumbnails corresponding to the image data.
摘要翻译: 提供浏览图像数据的方法和使用该图像数据的系统。 首先,提供多个图像数据。 为每个图像数据创建缩略图,其中各个缩略图具有相同的图像高度。 然后,根据缩略图创建幻灯片,并且将所有或一部分幻灯片显示在触敏显示单元中,以使用户浏览对应于图像数据的缩略图。
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公开(公告)号:US08703915B2
公开(公告)日:2014-04-22
申请号:US13379872
申请日:2010-06-22
申请人: Seyed Ali Jazayeri-Dezfuly , Guillaume Pierre Lebon , Fiona Hamilton Marshall , Christopher Gordon Tate , Nathan Robertson
发明人: Seyed Ali Jazayeri-Dezfuly , Guillaume Pierre Lebon , Fiona Hamilton Marshall , Christopher Gordon Tate , Nathan Robertson
IPC分类号: C07K14/705 , C12P21/00
CPC分类号: C07K14/705
摘要: A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence that defines a parent GPCR, wherein (i) the one or more mutations are located within a window of/plus or minus 5 residues, where/is the position of amino acid residue 2.46 in the parent GPCR when the parent GPCR is a Class 1 GPCR, or where/is the position of an equivalent amino acid residue in the parent GPCR when the parent GPCR is a Class 2 or 3 GPCR, and/or (ii) the one or more mutations are located within an amino acid sequence of transmembrane helix 7 in the parent GPCR which amino acid sequence interacts with the window of/plus or minus 5 residues, to provide one or more mutants of the parent GPCR with increased stability.
摘要翻译: 一种相对于亲本GPCR产生具有增加的稳定性的突变型G蛋白偶联受体(GPCR)的方法,所述方法包括在限定亲本GPCR的氨基酸序列中制备一个或多个突变,其中(i)所述一个或多个 突变位于/正或负5个残基的窗口内,其中当母体GPCR为1类GPCR时,母体GPCR中氨基酸残基2.46的位置,或其中/是等位氨基酸残基的位置 当母体GPCR为2或3 GPCR时,在母体GPCR中,和/或(ii)一个或多个突变位于母体GPCR中的跨膜螺旋7的氨基酸序列内,该氨基酸序列与窗口相互作用 的/加或减5个残基,以提供母体GPCR的一种或多种突变体具有增加的稳定性。
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公开(公告)号:US20120165507A1
公开(公告)日:2012-06-28
申请号:US13379872
申请日:2010-06-22
申请人: Seyed Ali Jazayeri-Dezfuly , Guillaume Pierre Lebon , Fiona Hamilton Marshall , Christopher Godon Tate , Nathan Robertson
发明人: Seyed Ali Jazayeri-Dezfuly , Guillaume Pierre Lebon , Fiona Hamilton Marshall , Christopher Godon Tate , Nathan Robertson
IPC分类号: C07K14/705 , C12P21/00
CPC分类号: C07K14/705
摘要: A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence that defines a parent GPCR, wherein (i) the one or more mutations are located within a window of / plus or minus 5 residues, where / is the position of amino acid residue 2.46 in the parent GPCR when the parent GPCR is a Class 1 GPCR, or where / is the position of an equivalent amino acid residue in the parent GPCR when the parent GPCR is a Class 2 or 3 GPCR, and/or (ii) the one or more mutations are located within an amino acid sequence of transmembrane helix 7 in the parent GPCR which amino acid sequence interacts with the window of / plus or minus 5 residues, to provide one or more mutants of the parent GPCR with increased stability.
摘要翻译: 一种相对于亲本GPCR产生具有增加的稳定性的突变型G蛋白偶联受体(GPCR)的方法,所述方法包括在限定亲本GPCR的氨基酸序列中制备一个或多个突变,其中(i)所述一个或多个 突变位于/正或负5个残基的窗口内,其中当母体GPCR为1类GPCR时,母体GPCR中氨基酸残基2.46的位置,或其中/是等位氨基酸残基的位置 当母体GPCR为2或3 GPCR时,在母体GPCR中,和/或(ii)一个或多个突变位于母体GPCR中的跨膜螺旋7的氨基酸序列内,该氨基酸序列与窗口相互作用 的/加或减5个残基,以提供母体GPCR的一种或多种突变体具有增加的稳定性。
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