-
公开(公告)号：US20090017509A1
公开(公告)日：2009-01-15
申请号：US12142095
申请日：2008-06-19
申请人： Holger BERK , Frank ZOCHER , Hans-Wolfram FLEMMING , Rainer GAULER , Rudolf LEHNERT , Wolfgang LAUX
发明人： Holger BERK , Frank ZOCHER , Hans-Wolfram FLEMMING , Rainer GAULER , Rudolf LEHNERT , Wolfgang LAUX
IPC分类号： C07D209/52 , C12P17/10 , C07C229/00
CPC分类号： C07D209/52 , C07C227/20 , C07C233/51 , C12P17/10 , C07C229/28
摘要： An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.
摘要翻译： 公开了一种制备雷米普利的改进方法，也是该方法中使用的中间体。
-
2.发明申请METHOD FOR THE PREPARATION OF OXAZOLES BY CONDENSING AROMATIC ALDEHYDES WITH ALPHA-KETOXIMES TO FORM N-OXIDES AND REACTING SAME WITH ACTIVATIVED ACID DERIVATIVES 有权通过将具有阿尔卡胶的芳族醛缩合形成N-氧化物并用活性酸衍生物反应的方法制备氧化剂的方法公开(公告)号：US20080058529A1
公开(公告)日：2008-03-06
申请号：US11754477
申请日：2007-05-29
申请人： Wolfgang HOLLA , Rolf-Ludwig HOERLEIN , Berndt KULITZSCHER , Wolfgang LAUX , Thomas STUEDEMANN , Christoph TAPPERTZHOFEN , Robert SCHEFFER
发明人： Wolfgang HOLLA , Rolf-Ludwig HOERLEIN , Berndt KULITZSCHER , Wolfgang LAUX , Thomas STUEDEMANN , Christoph TAPPERTZHOFEN , Robert SCHEFFER
IPC分类号： C07D263/30
CPC分类号： C07D263/32
摘要： The present invention is comprised of improved methods in the preparation of oxazoles which results in higher yields with less impurities and contaminants. Oxazoles constitute valuable intermediates in the synthesis of pharmaceutically active substances such as, for example peroxisome proliferator activated receptor (PPAR) agonists which are pharmaceutical actives which can have a positive influence on both lipid and glucose metabolism.
摘要翻译： 本发明包括改进的制备恶唑的方法，其导致较高的产率，较少的杂质和污染物。 恶唑在合成药物活性物质（例如过氧化物酶体增殖物激活受体（PPAR）激动剂）中是组成有价值的中间体，其是可以对脂质和葡萄糖代谢具有积极影响的药物活性物质。
-
公开(公告)号：US20120225103A1
公开(公告)日：2012-09-06
申请号：US13473724
申请日：2012-05-17
申请人： Frank THEOBALD , Wolfgang LAUX , Beatrix PLATT , Regine KAUFMANN
发明人： Frank THEOBALD , Wolfgang LAUX , Beatrix PLATT , Regine KAUFMANN
IPC分类号： A61K9/70 , A61M35/00 , A61K31/428
CPC分类号： A61K9/7061 , A61K31/428
摘要： This invention relates to a transdermal therapeutic system (TTS) releasing an active pramipexol agent during a time ranging from 4 to 7 days.
摘要翻译： 本发明涉及一种在4至7天的时间内释放活性的普拉克索剂的透皮治疗系统（TTS）。
-
4.发明申请METHOD FOR THE PRODUCTION OF OXAZOLES BY CONDENSING AROMATIC ALDEHYDES WITH a-KETOXIMES TO N-OXIDES AND THEN REACTING THE SAME WITH ACTIVATED ACID DERIVATIVES 有权通过将具有α-酮氧化物的芳族醛缩合到N-氧化物上并随后与活化酸衍生物反应来生产氧化剂的方法公开(公告)号：US20090286988A1
公开(公告)日：2009-11-19
申请号：US12509853
申请日：2009-07-27
申请人： Wolfgang HOLLA , Rolf-Ludwig HOERLEIN , Berndt KULITZSCHER , Wolfgang LAUX , Thomas STUEDEMANN , Christoph TAPPERTZHOFEN , Robert J. H. SCHEFFER
发明人： Wolfgang HOLLA , Rolf-Ludwig HOERLEIN , Berndt KULITZSCHER , Wolfgang LAUX , Thomas STUEDEMANN , Christoph TAPPERTZHOFEN , Robert J. H. SCHEFFER
IPC分类号： C07D263/30
CPC分类号： C07D263/32
摘要： The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using α-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, X3, o, n1 and n2 are as defined herein.
摘要翻译： 本发明涉及一种制备式Ⅳ化合物的方法，该方法是通过使式Ⅶ的α-酮肟通过式III的N-氧化物转化成式Ⅳ的卤代甲基唑将式Ⅰ的芳族醛转化成式Ⅳ的卤代甲基恶唑，其中R 1 ，R2，R3，R4，R5，R6，R7，R8，X1，X2，X3，o，n1和n2如本文所定义。
-
5.发明申请NOVEL INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF OXAZOLES AND PHARMACEUTICAL ACTIVES FOR THE REGULATION OF LIPID AND GLUCOSE METABOLISM 审中-公开用于制备用于调节脂质和葡萄糖代谢的氧化剂和药物活性的新型中间体化合物公开(公告)号：US20080114035A1
公开(公告)日：2008-05-15
申请号：US11928117
申请日：2007-10-30
申请人： Wolfgang HOLLA , Rolf-Ludwig HOERLEIN , Berndt KULITZSCHER , Wolfgang LAUX , Thomas STUEDEMANN , Christoph TAPPERTZHOFEN , Robert J. H. SCHEFFER
发明人： Wolfgang HOLLA , Rolf-Ludwig HOERLEIN , Berndt KULITZSCHER , Wolfgang LAUX , Thomas STUEDEMANN , Christoph TAPPERTZHOFEN , Robert J. H. SCHEFFER
IPC分类号： A61K31/4439 , A61K31/421 , C07D413/04
CPC分类号： C07D263/32
摘要： The present invention is directed to compounds of Formula III wherein the R1-R7 groups or substituents are defined herein. The present invention also comprises improved methods in the preparation of oxazoles in which the compounds of Formula III are intermediates and which results in higher yields with less impurities and contaminants. Oxazoles constitute valuable intermediates in the synthesis of pharmaceutically active substances such as, for example peroxisome proliferator activated receptor (PPAR) agonists which are pharmaceutical actives which can have a positive influence on both lipid and glucose metabolism.
摘要翻译： 本发明涉及式III化合物，其中R 1 -R 7基团或取代基在本文中定义。 本发明还包括制备恶唑的改进方法，其中式III的化合物是中间体，并且其产生更高的产率，更少的杂质和污染物。 恶唑在合成药物活性物质（例如过氧化物酶体增殖物激活受体（PPAR）激动剂）中是组成有价值的中间体，其是可以对脂质和葡萄糖代谢具有积极影响的药物活性物质。
-
-
-
-
搜索结果
5 条记录 (耗时 0.027 秒)
