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公开(公告)号：US20060122178A1
公开(公告)日：2006-06-08
申请号：US11271511
申请日：2005-11-10
申请人： Howard Cottam , Dennis Carson , Sylvie Barchechath
发明人： Howard Cottam , Dennis Carson , Sylvie Barchechath
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/429 , A61K31/424 , A61K31/4188 , C07D498/02 , C07D491/02 , C07D487/02
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention provides compounds that can protect mammalian cells from the damaging effects of chemotherapy, irradiation, or in other situations in which it is desirable to protect tissue from the consequences of clinical or environmental stress.
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公开(公告)号：US20080280903A1
公开(公告)日：2008-11-13
申请号：US11885463
申请日：2006-03-10
IPC分类号： A61K31/5377 , C07D213/02 , A61K31/4439 , A61K31/44 , C07D401/02 , C07D403/02 , A61K31/497 , A61K31/4545 , A61P43/00 , C07D413/02
CPC分类号： C07D513/04 , C07D213/20 , C07D215/227
摘要： The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode.
摘要翻译： 本发明提供了用作选择剂以防止无意的细胞死亡或组织损伤并可以减轻癌症治疗的副作用的化合物，例如口腔粘膜炎，脱发，胃肠上皮损伤引起的腹泻和骨髓抑制 。 此外，当细胞死亡是由受损细胞的信号引起的，例如作为创伤事件或缺血发作的结果产生的信号，这些化合物可用于防止过早的细胞死亡。
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公开(公告)号：US07601846B2
公开(公告)日：2009-10-13
申请号：US11271511
申请日：2005-11-10
IPC分类号： C07D513/04 , A61K31/429
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention provides compounds that can protect mammalian cells from the damaging effects of chemotherapy, irradiation, or in other situations in which it is desirable to protect tissue from the consequences of clinical or environmental stress.
摘要翻译： 本发明提供了可以保护哺乳动物细胞免受化学疗法，照射的损伤作用或其它期望保护组织免受临床或环境压力后果的其它情况的化合物。
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