公开(公告)号：US20240180867A1

公开(公告)日：2024-06-06

申请号：US18439896

申请日：2024-02-13

Applicant: Howard University

Inventor： Xinbin GU

IPC: A61K31/343 ,  A61K31/704 ,  A61P35/00

CPC classification number: A61K31/343 ,  A61K31/704 ,  A61P35/00

Abstract: The present disclosure provides methods related to treating triple-negative breast cancer (TNBC) in a mammal by administering salvianolic acid B (or a salt or solvate thereof) to promote ceramide-mediated apoptosis. In one form, the ceramide-mediated apoptosis of TNBC cells occurs by decreasing the level of one or more of glucosylceramide synthase and GM3 synthase in the subject through the use of an effective amount of salvianolic acid B. In another aspect, salvianolic acid B or its pharmaceutically acceptable salt or solvate is used as a medicament or in the manufacture of a medicament for treating TNBC.