公开(公告)号：US20210361739A1

公开(公告)日：2021-11-25

申请号：US16878809

申请日：2020-05-20

Applicant: Howard University

Inventor： Yousef TIZABI

IPC: A61K38/16

Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.

公开(公告)号：US20210386663A1

公开(公告)日：2021-12-16

申请号：US16897780

申请日：2020-06-10

Applicant: HOWARD UNIVERSITY

Inventor： Yousef TIZABI ,  Robert L. COPELAND

IPC: A61K9/00 ,  A61P25/16 ,  A61K31/465

Abstract: A method for treating or mitigating Parkinson's disease (PD) symptoms or progression, including administering an effective amount of nicotine to a subject in need thereof, via inhalation using a nicotine inhaler or via nasal spray using a nicotine nasal spray. Significant dose-dependent improvement of all symptoms by nicotine inhaler or nicotine nasal spray is expected. A novel treatment in PD is thus provided.

公开(公告)号：US20220249602A1

公开(公告)日：2022-08-11

申请号：US17729502

申请日：2022-04-26

Applicant: HOWARD UNIVERSITY

Inventor： Yousef TIZABI

IPC: A61K38/16

Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.