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公开(公告)号：US20060035891A1
公开(公告)日：2006-02-16
申请号：US11133419
申请日：2005-05-18
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： A61K31/5377 , A61K31/506 , C07D413/02
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
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公开(公告)号：US07858633B2
公开(公告)日：2010-12-28
申请号：US11567276
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US20080009494A1
公开(公告)日：2008-01-10
申请号：US11567276
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： A61K31/535 , A61K31/506 , A61P35/00 , C07D413/02
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US20070299060A1
公开(公告)日：2007-12-27
申请号：US11567506
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： A61K31/497 , A61K31/505 , A61K31/535 , A61K31/54 , A61P43/00 , C07D239/02 , C07D403/00 , C07D413/00 , C07D417/00 , C12N5/06
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US07868013B2
公开(公告)日：2011-01-11
申请号：US11567506
申请日：2006-12-06
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Mark Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US07754714B2
公开(公告)日：2010-07-13
申请号：US11133419
申请日：2005-05-18
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim M. V. Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim M. V. Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
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公开(公告)号：US08410093B2
公开(公告)日：2013-04-02
申请号：US12951949
申请日：2010-11-22
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US20110152518A1
公开(公告)日：2011-06-23
申请号：US12951949
申请日：2010-11-22
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim Markovtsov
IPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D239/48
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
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公开(公告)号：US08415365B2
公开(公告)日：2013-04-09
申请号：US12030031
申请日：2008-02-12
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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公开(公告)号：US08399472B2
公开(公告)日：2013-03-19
申请号：US12193627
申请日：2008-08-18
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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